Chemical Property of Rescinnamine
Chemical Property:
- Appearance/Colour:white to cream powder
- Vapor Pressure:8.5E-23mmHg at 25°C
- Melting Point:238 C
- Refractive Index:1.5300 (estimate)
- Boiling Point:756.8°C at 760 mmHg
- PKA:pKa 6.4 (Uncertain)
- Flash Point:411.5°C
- PSA：117.78000
- Density:1.31g/cm3
- LogP:4.50860
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)
- XLogP3:4.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:11
- Exact Mass:634.28903092
- Heavy Atom Count:46
- Complexity:1080
- Transport DOT Label:Poison
- Purity/Quality:
-
99% *data from raw suppliers
Rescinnamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
25-20/21/22
- Safety Statements:
22-45-36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C=CC6=CC(=C(C(=C6)OC)OC)OC
- Isomeric SMILES:CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)/C=C/C6=CC(=C(C(=C6)OC)OC)OC
- Recent EU Clinical Trials:NON-INFERIORITY STUDY OF A METRONIDAZOLE 0.75% CREAM VERSUS REFERENCE THERAPY IN THE LOCAL TREATMENT OF PAPULOPUSTULAR ROSACEA.
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Description
This Rauwolfia alkaloid is found in the barks of R. serpentina and R. vomitora
and was originally given the name Reserpinine, this being altered to avoid
confusion with another alkaloid of the same name (q.v.). The base has [α]17D - 99.2° (c 1.3, CHCI3). From chemical degradation and spectroscopic analysis,
the structure has been established as the 3:4: 5-trimethoxycinnamoyl ester of
reserpic acid.
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Uses
Rescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent. Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.
