(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one
CAS No.:1223432-76-5
Molecular Formula:C₁₆H₂₀FN₃O₄
Molecular Weight:337.351
Hs Code.:

Synonyms:(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

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Chemical Property of (R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

Chemical Property:

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Technology Process of (R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

There total 5 articles about (R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1223432-74-3
(R)-4-[3-fluoro-4-(4-methoxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester

: 1223432-76-5
(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

Guidance literature:: (R)-4-[3-fluoro-4-(4-methoxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In ethyl acetate; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; Cooling with ice;

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1223432-76-5
(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C

2.1: copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 7 h / Reflux

3.1: sodium hydroxide; water / 1,2-dimethoxyethane / 20 °C

3.2: Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice

5.1: hydrogenchloride / ethyl acetate / 20 °C

5.2: Cooling with ice

With hydrogenchloride; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1223432-70-9
4-(4-bromo-3-fluorobenzoyl)piperazine-1-carboxylic acid tert-butyl ester

: 1223432-76-5
(R)-3-[2-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 7 h / Reflux

2.1: sodium hydroxide; water / 1,2-dimethoxyethane / 20 °C

2.2: Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Cooling with ice

4.1: hydrogenchloride / ethyl acetate / 20 °C

4.2: Cooling with ice

With hydrogenchloride; water; sodium hydride; sodium hydroxide; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;