Multi-step reaction with 9 steps
1.1: potassium hydroxide; hydroxylamine hydrochloride / tetrahydrofuran; methanol; water / 4 h / 20 °C / pH 9
2.1: hydrogenchloride; methyl orange; sodium cyanoborohydride / tetrahydrofuran; methanol; water / 16 h / pH 2
2.2: pH 7 / Alkaline aqueous solution
3.1: benzene / Heating / reflux
4.1: titanium(IV) isopropylate / toluene / 0.33 h / 140 °C / Microwave irradiation
4.2: 1 h
5.1: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C
6.1: trimethylaluminum / hexanes; dichloromethane / 0.25 h / 20 °C
6.2: 16 h / 20 °C
6.3: 2 h / 20 °C
7.1: potassium acetate; caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4.5 h / 60 °C
8.1: sodium cyanoborohydride; acetic acid / methanol; water / 2 h / 20 °C
9.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h
With
titanium(IV) isopropylate; hydrogenchloride; potassium hydroxide; hydroxylamine hydrochloride; methyl orange; trimethylaluminum; potassium acetate; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; pyridine hydrogenfluoride; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; hexanes; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;