Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate

Base Information

• Chemical Name: Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate
• CAS No.: 224452-39-5
• Molecular Formula: C₂₇H₂₇N₃O₈
• Molecular Weight: 521.527
• Mol file: 224452-39-5.mol

Synonyms:Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate

Chemical Property of Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate

There total 3 articles about Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,6-Pyridinedicarbonyl dichloride (3739-94-4) + L-Tyr-OMe (1080-06-4) → Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate (224452-39-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo982472q

Reference yield:

Pyridine-2,6-dicarboxylic acid (499-83-2) → Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate (224452-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1,4-dioxane / 1 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/acs.inorgchem.1c03728

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → Dimethyl N,N'-(pyridine-2,6-dicarbonyl)di-(S)-tyrosinate (224452-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; thionyl chloride / 4.5 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

With methanol; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/acs.inorgchem.1c03728

upstream raw materials:

2,6-Pyridinedicarbonyl dichloride

L-Tyr-OMe

L-tyrosine

Pyridine-2,6-dicarboxylic acid

Downstream raw materials:

N,N-bis-[1-carboxy-2-(p-hydroxybenzyl)]-2,6-(diaminocarbonyl)-pyridine

N²,N^2'-(Pyridine-2,6-dicarbonyl)di(S)tyrosinehydrazide