N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide
CAS No.:186415-02-1
Molecular Formula:C₂₇H₃₆N₆O₅
Molecular Weight:524.62
Hs Code.:

Synonyms:N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

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Chemical Property of N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

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Technology Process of N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

There total 5 articles about N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-(2,2-Dimethyl-propionylamino)-6-{[(E)-3,4,5-trimethoxy-phenylimino]-methyl}-pyrido[2,3-d]pyrimidin-4-yl)-2,2-dimethyl-propionamide

: 186415-02-1
N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

Guidance literature:: With triethylamine-borane; In acetic acid; for 4h; Yield given; Ambient temperature;
DOI:10.1021/jm9606913

Reference yield:

: 152941-69-0
2,4-diamino-6-bromopyrido<2,3-d>pyrimidine

: 186415-02-1
N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 8 h / Heating

2: 47 percent / Pd(OAc)2, (o-tol)3P, CuI, Et₃N / acetonitrile / 48 h / Heating

3: 80 percent / O₃ / CH₂Cl₂; methanol / -78 °C

4: glacial AcOH / 18 h / Ambient temperature

5: BH₃*Et₃N / acetic acid / 4 h / Ambient temperature

With pyridine; palladium diacetate; copper(l) iodide; triethylamine-borane; ozone; acetic acid; triethylamine; tris-(o-tolyl)phosphine; In methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jm9606913

Reference yield:

: 138609-27-5
2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine

: 186415-02-1
N-{2-(2,2-Dimethyl-propionylamino)-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidin-4-yl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / Pd(OAc)2, (o-tol)3P, CuI, Et₃N / acetonitrile / 48 h / Heating

2: 80 percent / O₃ / CH₂Cl₂; methanol / -78 °C

3: glacial AcOH / 18 h / Ambient temperature

4: BH₃*Et₃N / acetic acid / 4 h / Ambient temperature

With palladium diacetate; copper(l) iodide; triethylamine-borane; ozone; acetic acid; triethylamine; tris-(o-tolyl)phosphine; In methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jm9606913