Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate

Base Information

• Chemical Name: Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate
• CAS No.: 1293362-39-6
• Molecular Formula: C₂₃H₁₇O₄S*Na
• Molecular Weight: 412.441
• Mol file: 1293362-39-6.mol

Synonyms:Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate

Chemical Property of Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate

There total 8 articles about Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzenesulfonic acid-4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl ester (1293362-49-8) → Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate (1293362-39-6)

Guidance literature:

With 1-piperidinoethanol; sodium; In toluene; at 20 - 50 ℃; for 1.83333h;

Reference yield:

[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone (63676-19-7) → Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate (1293362-39-6)

Guidance literature:

With tert-butyl methyl ether; sodium methylate; In methanol; at -17 - 20 ℃; for 4h;

Reference yield:

p-benzenesulfonyloxybenzoyl chloride → Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate (1293362-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iron(III) sulfate pentahydrate; iron / toluene / 5.5 h / 100 - 111 °C

2.1: sodium hydroxide; water; tetrabutylammomium bromide / toluene; methanol / 6 h / 20 °C / Reflux

2.2: 20 °C

3.1: sodium methylate; tert-butyl methyl ether / methanol / 4 h / -17 - 20 °C

With tert-butyl methyl ether; tetrabutylammomium bromide; water; sodium methylate; sodium hydroxide; iron(III) sulfate pentahydrate; iron; In methanol; toluene;

upstream raw materials:

Ethyl 4-hydroxybenzoate

[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone

ethyl 4-((phenylsulfonyl)oxy)benzoate

Methyl 4-((phenylsulfonyl)oxy)benzoate

Refernces

• 1、 -. "A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES". . . Retrieved 2011/05/06.
• 2、 -. "A process for preparing benzo[b]thiophene derivatives". Page/Page column 25. . Retrieved 2011/06/10.