63676-19-7

Basic information

• Product Name: Methanone, (4-hydroxyphenyl)[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-
• CAS NO: 63676-19-7
• Molecular Formula: C23H18O4S
• Molecular Weight: 390.46
• Mol File: 63676-19-7.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Methanone, (4-hydroxyphenyl)[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-hydroxyphenyl)[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-(63676-19-7)
• EPA Substance Registry System: Methanone, (4-hydroxyphenyl)[6-methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl]-(63676-19-7)

Safety Data

• Hazardous Substances Data: 63676-19-7(Hazardous Substances Data)

Upstream product

• 63675-87-6 [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-methoxy-phenyl)-methanone 
• 75-08-1 ethanethiol 
• 15570-12-4 3-methoxybenzenethiol 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 63675-73-0 α-(3-methoxyphenyl-thio)-4-methoxyacetophenone 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 27914-73-4 4-acetoxybenzoyl chloride 
• 7099-91-4 p-methoxybenzoylformic acid 
• 1163701-10-7 (5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane 
• 200625-51-0 [{4-(1,1-dimethylethyl)dimethylsiloxyphenyl}ethynyl]trimethylsilane 
• 133430-99-6 4-(tert-butyldimethylsilyloxy)iodobenzene 
• 540-38-5 p-Iodophenol 
• 4897-68-1 2-iodo-4-methoxybromobenzene 

Downstream Products

• 222401-06-1 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[(1-Methylpiperidin-3-yl) methoxy]benzoyl) benzo [b]thiophene 
• 222401-07-2 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-methylpiperidin-3-oxy]benzoyl)benzo[b]thiophene 
• 222400-96-6 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-methylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 
• 222400-99-9 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-hexylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 
• 222401-05-0 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-benzylpyrrolidin-3-oxy]benzoyl)benzo[b]thiophene 
• 222401-09-4 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[2-piperidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene 
• 222401-10-7 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[2-pyrrolidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene 
• 222401-08-3 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-3-oxy]benzoyl)benzo[b]thiophene 
• 222401-04-9 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[(1-hexylpiperidin-3-yl)methoxy]benzoyl)benzo[b]thiophene 
• 222400-97-7 6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 
• 176977-60-9 [6-Methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl][4-trifluoromethylsulfonyloxyphenyl]methanone 
• 84541-36-6 [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride 
• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 1293362-39-6 Sodium 4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenolate 

Relevant articles and documents

ESTROGEN RECEPTOR TARGETING ANTAGONISTS

The present disclosure relates to compounds that act as antagonists via binding to the ER ligand binding domain non-covalently or covalently, or act as both antagonists and ER protein degraders, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ breast cancer.

Method for synthesizing D-Diphenyl formyl-tartaric acid and co-producing methyl benzoate

The invention provides a method for synthesizing D-dibenzoyl tartaric acid and co-producing methyl benzoate. The method comprises the following steps that S1 an organic solvent, D-tartaric acid and lewis acid are added into a reaction bottle, stirred and heated, benzoyl chloride is added dropwise, heat preservation is conducted for 30-90 minutes, a product is cooled to be at 0-5 DEG C, suction filtration is conducted, and a filter cake A and filtrate A are obtained; S2 methyl alcohol is added into the filter cake A and stirred for 30 minutes, suction filtration is conducted, and a filter cakeB and filtrate B are obtained; S3 the filter cake B is added into pure water, heating and back flowing are conducted for 1.5-2.5 hours, a product is cooled to be at 25-30 DEG C, suction filtration isconducted, the filter cake is dried, and D-dibenzoyl tartaric acid is obtained; and S4 an esterification reaction catalyst is added into the filtrate B, back flowing is conducted, alkali is added to adjust the pH value, atmospheric distillation is conducted, water is added to wash the product, vacuum rectification is conducted, and the methyl benzoate is obtained. The method has the advantages that the technology is simple, the operation is convenient, the condition is moderate, the product chromaticity is good, the method is environmentally friendly, the cost is low, the product yield is high, and the product purity is high.

A pizotifen derivative and its preparation method (by machine translation)

The invention discloses a pizotifen derivatives, its molecular formula is The preparation of the pizotifen derivatives raw materials used is simple, its reaction condition is easy to reach, and has a higher yield, in the reaction process also will not produce harmful substances, is a raw material and the reaction conditions are simple pizotifen derivatives. (by machine translation)