N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

Base Information

Chemical Name:N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide
CAS No.:123723-97-7
Molecular Formula:C₁₈H₁₉N₃O₃
Molecular Weight:325.367
Hs Code.:

Synonyms:N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

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Chemical Property of N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

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Technology Process of N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

There total 4 articles about N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 123723-88-6
[3-(1-Methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetic acid

: 593-56-6
N-methoxylamine hydrochloride

: 123723-97-7
N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00163a039

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 123723-97-7
N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / cesium carbonate, potassium iodide / acetone / Heating

2: 77 percent / 1 N NaOH / tetrahydrofuran / Heating

3: 40 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide, Et₃N / tetrahydrofuran / Ambient temperature

With sodium hydroxide; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; In tetrahydrofuran; acetone;
DOI:10.1021/jm00163a039

Reference yield:

: 4760-35-4
2-chloromethyl-1-methyl-1H-benzimidazole

: 123723-97-7
N-Methoxy-2-[3-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / cesium carbonate, potassium iodide / acetone / Heating

2: 77 percent / 1 N NaOH / tetrahydrofuran / Heating

3: 40 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide, Et₃N / tetrahydrofuran / Ambient temperature

With sodium hydroxide; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; In tetrahydrofuran; acetone;
DOI:10.1021/jm00163a039