(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate
CAS No.:1620056-57-6
Molecular Formula:C₂₇H₂₈BrClF₂N₆O₄S
Molecular Weight:685.977
Hs Code.:

Synonyms:(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

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Technology Process of (S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

There total 11 articles about (S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620056-59-8
(S)-tert-butyl (1-(5-amino-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

: 1620056-57-6
(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 0 ℃;

Reference yield:

: 186593-43-1
5-amino-3-bromo-2-methylpyridine

: 1620056-57-6
(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

7: hydrazine hydrate / ethanol / 2 h / 20 °C

8: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Sealed tube; Inert atmosphere

9: N-Bromosuccinimide / acetonitrile / 0 °C

With hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; sodium acetate; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; hydrazine hydrate; copper(II) sulfate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1620056-30-5
2-(5-bromo-6-methylpyridin-3-yl)isoindoline-1,3-dione

: 1620056-57-6
(S)-tert-butyl (1-(5-amino-6-bromo-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

2: copper(II) sulfate / dichloromethane / 2 h / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

4: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 °C

6: hydrazine hydrate / ethanol / 2 h / 20 °C

7: sodium hydrogencarbonate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Sealed tube; Inert atmosphere

8: N-Bromosuccinimide / acetonitrile / 0 °C

With hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate; hydrazine hydrate; copper(II) sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;