186593-43-1

Basic information

• Product Name: 5-AMINO-3-BROMO-2-METHYLPYRIDINE
• Synonyms: 5-AMINO-3-BROMO-2-METHYLPYRIDINE;3-Bromo-5-Amino-2-Picoline;5-Bromo-6-methylpyridin-3-amine;5-Amino-3-bromo-2-methylp...;2-Methyl-3-broMo-5-aMinopyridine;3-PyridinaMine, 5-broMo-2-chloro-6-Methyl-;5-BroMo-6-Methyl-pyridin-3-ylaMine;5-AMINO-3-BROMO-2-PICOLINE
• CAS NO: 186593-43-1
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.03718
• Product Categories: Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 186593-43-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 103.0 to 108.0 °C
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 123.9 °C
• Appearance: /
• Density: 1.593 g/cm³
• Vapor Pressure: 0.00359mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.53±0.20(Predicted)
• CAS DataBase Reference: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(186593-43-1)
• EPA Substance Registry System: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(186593-43-1)

Safety Data

• Hazardous Substances Data: 186593-43-1(Hazardous Substances Data)

Usage

Uses

5-?Amino-?3-?bromo-?2-?methylpyridine is a versatile reactant used in different synthetic preparations. It was used in the synthesis of amino acids by asymmetric enzymic transamination of keto acids in presence of axially chiral pyridoxamines as catalysts.

InChI:InChI=1/C6H7BrN2/c1-4-6(7)2-5(8)3-9-4/h2-3H,8H2,1H3

Upstream product

• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 
• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 7439-89-6 iron 
• 15862-36-9 2,3-dibromo-5-nitropyridine 
• 15862-33-6 3-bromo-2-hydroxy-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 1190862-72-6 5-bromo-6-methylnicotinic acid 

Downstream Products

• 1621225-24-8 5-chloro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 131036-39-0 3-bromo-5-chloro-2-methylpyridine 
• 1609578-84-8 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methylpyridin-3-amine 
• 1628838-42-5 N-(2-methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide 

Relevant articles and documents

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Anti-tumor activity with acetylene derivatives

The present invention relates to an aromatic ring disubstituted acetylene derivative of formula I, a pharmaceutical composition comprising the compound, and a use of the compound and of the pharmaceutical composition in the treatment and/or prevention of tumors, where A, B, T, M, Ra, Rb, Rt, m, n, and p are as defined in the present document.

A 2-amino-thiazole compounds (by machine translation)

The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)