4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile

Base Information

• Chemical Name: 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile
• CAS No.: 103585-29-1
• Molecular Formula: C₂₀H₂₅N₅O₄
• Molecular Weight: 399.45
• Mol file: 103585-29-1.mol

Synonyms:4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile

Chemical Property of 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile

There total 4 articles about 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

crotononitrile (4786-20-3,627-26-9) + α-morpholino-α-(4-morpholino-3-nitro-phenyl)-acetonitrile (139080-77-6) → 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile (103585-29-1)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

Morpholin-4-yl-(4-morpholin-4-yl-3-nitro-phenyl)-methanol → 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile (103585-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O / 16 h / Heating

2: 1.) methanolic KOH / 1.) THF, 25 deg C, 10 min, 2.) THF, RT, 5 h

With potassium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/0223-5234(91)90121-3

Reference yield:

but-2-enenitrile (4786-20-3,627-26-9) + α-morpholino-α-(4-morpholino-3-nitro-phenyl)-acetonitrile (139080-77-6) → 4-(4-morpholino-3-nitrophenyl)-4-cyano-4-morpholino-3-methyl-butyronitrile (103585-29-1)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) THF, 25 deg C, 10 min, 2.) THF, RT, 5 h;

DOI:10.1016/0223-5234(91)90121-3

upstream raw materials:

but-2-enenitrile

α-morpholino-α-(4-morpholino-3-nitro-phenyl)-acetonitrile

4-chloro-3-nitro-benzaldehyde

crotononitrile

Downstream raw materials:

6-(3-propionamido-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one

5-methyl-6-(4-morpholino-3-nitrophenyl)-4,5-dihydro-2H-pyridazine-3-one

3-(4-morpholino-3-nitrobenzoyl)butyric acid

6-(3-acetamido-4-morpholinophenyl)-5-methyl-4,5-dihydro-2H-pyridazine-3-one