Technology Process of ethyl 3-(2,4-difluoroanilino)-2-(2,4,5-trifluorobenzoyl)acrylate
There total 5 articles about ethyl 3-(2,4-difluoroanilino)-2-(2,4,5-trifluorobenzoyl)acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) aluminum chloride / 1.) 50 deg C, 1 h, 2.) 80 deg C, 22 h
2: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C
3: thionyl chloride / 4 h / 80 °C
4: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h
5: 1.) acetic anhydride / 1.) 125 deg C, 2 h, 2.) methylene chloride, 45 min
With
sodium hydroxide; sodium hypochlorite; n-butyllithium; aluminium trichloride; thionyl chloride; biquinoline; acetic anhydride;
In
water;
DOI:10.1021/jm00105a025
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C
2: thionyl chloride / 4 h / 80 °C
3: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h
4: 1.) acetic anhydride / 1.) 125 deg C, 2 h, 2.) methylene chloride, 45 min
With
sodium hydroxide; sodium hypochlorite; n-butyllithium; thionyl chloride; biquinoline; acetic anhydride;
In
water;
DOI:10.1021/jm00105a025
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) (COCl)2, 2.) C3H7MgCl / 1.) CH2Cl2, DMF, 2.) THF
2: 1.) Ac2O / 2.) Et2O
With
oxalyl dichloride; C3H7MgCl; acetic anhydride;
DOI:10.1021/jm00015a021
