1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

Base Information

Chemical Name:1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea
CAS No.:1353754-89-8
Molecular Formula:C₁₃H₁₂BrN₅O₄
Molecular Weight:382.173
Hs Code.:

Synonyms:1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

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Chemical Property of 1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

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Technology Process of 1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

There total 1 articles about 1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 187235-71-8
(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine hydrochloride

: 2493-02-9
4-bromophenyl isocyanate

: 1353754-89-8
1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

Guidance literature:: With 4-methyl-morpholine; dibutyltin diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;
DOI:10.1021/jm2012276

Reference yield: 92.0%

: 1353754-89-8
1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

: 351019-18-6
(6-fluoropyridin-3-yl)boronic acid

: 1353754-50-3
1-[4-(6-fluoropyridin-3-yl)phenyl]-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

Guidance literature:: 1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea; (6-fluoropyridin-3-yl)boronic acid; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm2012276

Reference yield: 83.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1353754-89-8
1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea

: 1353754-49-0
1-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-3-{4-[6-(trifluoromethyl)pyridin-3-yl]phenyl}urea

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 1-(4-bromophenyl)-3-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]urea; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm2012276