(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

Base Information

Chemical Name:(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one
CAS No.:859520-63-1
Molecular Formula:C₃₆H₃₈O₄Si
Molecular Weight:562.781
Hs Code.:

Synonyms:(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

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Chemical Property of (6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

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Technology Process of (6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

There total 8 articles about (6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 859520-66-4
(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-3,6-dihydro-2H-pyran-2-one

: 859520-63-1
(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1055/s-2005-868518

Reference yield:

: 859520-64-2
(tert-butyl-diphenyl-silanyloxy)-phenyl-acetic acid methyl ester

: 859520-63-1
(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / i-Bu₂AlH / diethyl ether / 0.5 h / -78 °C

2: 78 percent / toluene / 48 h / 70 °C

3: 84 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h / 20 °C

4: 90 percent / m-CPBA; BF₃*OEt₂ / CH₂Cl₂ / 14 h / 0 - 20 °C

5: 91 percent / DBU / tetrahydrofuran / 18 h / 20 °C

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1055/s-2005-868518

Reference yield:

: 859520-62-0
({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

: 859520-63-1
(6R)-6-[(1S,2R)-1-(benzyloxy)-2-{[tert-butyl(diphenyl)silyl]oxy}-2-phenylethyl]-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / m-CPBA; BF₃*OEt₂ / CH₂Cl₂ / 14 h / 0 - 20 °C

2: 91 percent / DBU / tetrahydrofuran / 18 h / 20 °C

With boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2005-868518