({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane
CAS No.:859520-62-0
Molecular Formula:C₃₈H₄₄O₄Si
Molecular Weight:592.85
Hs Code.:

Synonyms:({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

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Chemical Property of ({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

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Technology Process of ({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

There total 5 articles about ({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859520-64-2
(tert-butyl-diphenyl-silanyloxy)-phenyl-acetic acid methyl ester

: 859520-62-0
({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / i-Bu₂AlH / diethyl ether / 0.5 h / -78 °C

2: 78 percent / toluene / 48 h / 70 °C

3: 84 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1055/s-2005-868518

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 859520-62-0
({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / p-TsOH / 3 h / Heating

2: 93 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

3: 83 percent / i-Bu₂AlH / diethyl ether / 0.5 h / -78 °C

4: 78 percent / toluene / 48 h / 70 °C

5: 84 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1055/s-2005-868518

Reference yield:

: 20698-91-3
(R)-methyl mandelate

: 859520-62-0
({(1R,2S)-2-(benzyloxy)-2-[(2R,6S)-6-ethoxy-5,6-dihydro-2H-pyran-2-yl]-1-phenylethyl}oxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 83 percent / i-Bu₂AlH / diethyl ether / 0.5 h / -78 °C

3: 78 percent / toluene / 48 h / 70 °C

4: 84 percent / NaH; Bu₄NI / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1055/s-2005-868518