di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

Base Information

Chemical Name:di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate
CAS No.:1429312-18-4
Molecular Formula:C₂₈H₃₃ClN₄O₅S
Molecular Weight:573.113
Hs Code.:

Synonyms:di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

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Chemical Property of di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

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Technology Process of di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

There total 6 articles about di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1429312-19-5
2-[2,2-bis(tert-butoxycarbonyl)hydrazino]-4-phenylthiazole-5-carboxylic acid

: 41456-55-7
3-chloro-N,4-dimethylbenzenamine

di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate: 1429312-18-4
di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1429312-15-1
t-butyl N-tert-butoxycarbon-N-[(4-phenylthiazol-2-yl)amino]carbamate

di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate: 1429312-18-4
di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium hydroxide / tetrahydrofuran / 48 h / 20 °C

3.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 3 h / 20 °C

With n-butyllithium; 2-chloro-1-methyl-pyridinium iodide; triethylamine; diisopropylamine; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 34176-52-8
2-hydrazino-4-phenylthiazole

di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate: 1429312-18-4
di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 0 - 20 °C

2.1: triethylamine; dmap / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

4.1: lithium hydroxide / tetrahydrofuran / 48 h / 20 °C

5.1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 3 h / 20 °C

With dmap; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide; triethylamine; diisopropylamine; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane;