41456-55-7

Usage

Uses

Used in Pharmaceutical Industry:
(3-Chloro-4-methyl-phenyl)-methyl-amine is used as a building block for the synthesis of pharmaceuticals, contributing to the development of various medicinal compounds.
Used in Agrochemical Industry:
(3-Chloro-4-methyl-phenyl)-methyl-amine serves as an intermediate in the production of agrochemicals, playing a role in the creation of substances used in agriculture to manage pests and enhance crop yields.
Used in Fine Chemicals Production:
(3-Chloro-4-methyl-phenyl)-methyl-amine is utilized in the synthesis of other fine chemicals, which are high-purity, high-value chemicals used in various specialized applications.
Used in Dyes and Pigments Industry:
It is employed as an intermediate in the production of dyes and pigments, contributing to the coloration and properties of these substances used in various industries.
Used in Medicinal Chemistry and Drug Discovery:
(3-Chloro-4-methyl-phenyl)-methyl-amine has potential applications in medicinal chemistry and drug discovery, where it may be used to develop new therapeutic agents.
Used in Material Science:
(3-Chloro-4-methyl-phenyl)-methyl-amine also has applications in material science, where its unique chemical and physical properties can be leveraged to create new materials with specific characteristics.

Upstream product

• 67-56-1 methanol 
• 95-74-9 3-chloro-p-toluidine 
• 75560-65-5 3-chloro-N,N,4-trimethylaniline 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1429312-18-4 di-tert-butyl 2-(5-((3-chloro-4-methylphenyl)(methyl)carbamoyl)-4-phenylthiazol-2-yl)hydrazine-1,1-dicarboxylate 

Relevant academic research and scientific papers

Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2

A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.

Photodriven Photocatalyst/Metal-Free Direct C-C/C-N Bond Formation: Synthesis of Indoles via EDA Complexes

The photodriven direct C-C/C-N bond formation initiated by electron donor-acceptor (EDA) complexes for the synthesis of indoles has been accomplished via [3+2] annulations of secondary arylamines with alkynes using IC4F9 as oxidants in the absence of any photocatalysts and metals. This green transformation exhibits the advantages of operational simplicity, good functional tolerances, and mild reaction conditions. The in situ generated EDA complexes derived from arylamines with alkynes were characterized by UV-vis absorption spectrometry and NMR titration experiments.

N-Methylation of Amines with Methanol Catalyzed by a Cp?Ir Complex Bearing a Functional 2,2′-Bibenzimidazole Ligand

A new type of Cp?Ir complex bearing a functional 2,2′-bibenzimidazole ligand was designed, synthesized, and found to be a highly effective and general catalyst for the N-methylation of a variety of amines with methanol in the presence of a weak base (0.3 equiv of Cs2CO3).

General and efficient method for direct N-monomethylation of aromatic primary amines with methanol

The direct N-monomethylation of aromatic primary amines, including arylamines, arylsulfonamides and amino-azoles, using methanol as a methylating agent has been accomplished in the presence of a [CpIrCl2]2/NaOH system. From both synthetic and environmental points of view, the reaction is highly attractive because of low catalyst loading, broad substrate scope and excellent selectivities.