(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

Base Information

Chemical Name:(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide
CAS No.:1287746-37-5
Molecular Formula:C₂₇H₄₀ClN₃O₃
Molecular Weight:490.086
Hs Code.:

Synonyms:(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

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Chemical Property of (7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

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Technology Process of (7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

There total 4 articles about (7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.83%

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

: 1287746-41-1
(7R)-1-azaspiro[4.4]nonane-7-carboxylic acid

: 1287746-42-2
(7R)-3-chloro-1-azaspiro[4.4]nonane-7-carboxylic acid

: 1287746-37-5
(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

: 1287746-35-3
(7R)-3-chloro-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

Reference yield:

: 1287745-32-7
(R)-benzyl 3-oxocyclopentanecarboxylate

: 1287746-37-5
(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 16 h / 20 °C

2: Phenylselenyl chloride / acetonitrile / 18 h / 80 °C

3: hydrogen / palladium on carbon / methanol / 3.5 h / 20 °C / 2068.65 Torr / Inert atmosphere

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 h / 20 °C

With Phenylselenyl chloride; ammonia; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1287745-28-1
(1R)-benzyl 3-allyl-3-aminocyclopentanecarboxylate

: 1287746-37-5
(7R)-N-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-1-azaspiro[4.4]nonane-7-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Phenylselenyl chloride / acetonitrile / 18 h / 80 °C

2: hydrogen / palladium on carbon / methanol / 3.5 h / 20 °C / 2068.65 Torr / Inert atmosphere

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 h / 20 °C

With Phenylselenyl chloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;