(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

Base Information

Chemical Name:(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt
CAS No.:946593-51-7
Molecular Formula:C₁₈H₂₇ClN₂O₂*ClH
Molecular Weight:375.339
Hs Code.:

Synonyms:(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

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Chemical Property of (R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

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Technology Process of (R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

There total 8 articles about (R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946594-20-3
tert-butyl (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2.5h;

Reference yield:

: 690660-22-1
(S)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-4-ol

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane;

Reference yield:

: 324769-06-4
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - -60 °C

1.2: 2 h / -78 - -60 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

3.1: butanone; water / 20 °C / Reflux

4.1: sodium hydroxide / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

With hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; butanone;