O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite

Base Information

• Chemical Name: O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite
• CAS No.: 404951-72-0
• Molecular Formula: C₁₆H₂₇N₂O₄P
• Molecular Weight: 342.375
• Mol file: 404951-72-0.mol

Synonyms:O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite

Chemical Property of O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite

There total 3 articles about O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

O,O'-bis-(4-nitrophenyl) N,N-diisopropylphosphoramidite (153413-65-1) + tert-butyl alcohol (75-65-0) → O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite (404951-72-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1039/b103082p

Reference yield:

N,N-diisopropylphosphoramide dichloride (921-26-6) → O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite (404951-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 2 h / 20 °C

2: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1039/b103082p

Reference yield:

4-nitrophenol sodium salt (824-78-2) → O-tert-butyl O'-(4-nitrophenyl) N,N-diisopropylphosphoramidite (404951-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / tetrahydrofuran / 2 h / 20 °C

2: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1039/b103082p

upstream raw materials:

O,O'-bis-(4-nitrophenyl) N,N-diisopropylphosphoramidite

tert-butyl alcohol

N,N-diisopropylphosphoramide dichloride

4-nitrophenol sodium salt