ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate

Base Information

• Chemical Name: ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate
• CAS No.: 1441119-45-4
• Molecular Formula: C₂₀H₂₂O₈
• Molecular Weight: 390.39
• Mol file: 1441119-45-4.mol

Synonyms:ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate

Chemical Property of ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate

There total 1 articles about ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-bromo-7-methoxybenzo[1,3]dioxole-5-carboxylic acid ethyl ester (418755-58-5) + 3,4,5-trimethoxyphenylboronic Acid (182163-96-8) → ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate (1441119-45-4)

Guidance literature:

With potassium phosphate; palladium diacetate; CyJohnPhos; In toluene; at 80 - 90 ℃; for 10h; Inert atmosphere;

DOI:10.1002/ejoc.201201247

Reference yield: 88.0%

ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate (1441119-45-4) → [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol (870094-81-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/ejoc.201201247

Reference yield:

ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate (1441119-45-4) → (E)-1-[(3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)methoxy]-2-(triisopropylsilyloxymethyl)but-2-ene (1441119-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / hexane; toluene / 1.5 h / -78 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene; 2: |Williamson Ether Synthesis;

DOI:10.1002/ejoc.201201247

upstream raw materials:

6-bromo-7-methoxybenzo[1,3]dioxole-5-carboxylic acid ethyl ester

3,4,5-trimethoxyphenylboronic Acid

Downstream raw materials:

[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

(E)-1-[(3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)methoxy]-2-(triisopropylsilyloxymethyl)but-2-ene

(1R,2S)-2-methyl-1-(3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)-3-[(triisopropylsilyloxy)methyl]but-3-en-1-ol

(1R,2S)-2-methyl-3-methylene-1-(3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)butane-1,4-diol