[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

Base Information

• Chemical Name: [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol
• CAS No.: 870094-81-8
• Molecular Formula: C₁₈H₂₀O₇
• Molecular Weight: 348.353
• Mol file: 870094-81-8.mol

Synonyms:[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

Chemical Property of [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol

There total 6 articles about [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester (870094-80-7) → [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol (870094-81-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 14h; Heating;

DOI:10.1002/anie.200501890

Reference yield: 88.0%

ethyl (3',4',5',6-tetramethoxy-4,5-methylenedioxybiphenyl-2-yl)carboxylate (1441119-45-4) → [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol (870094-81-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/ejoc.201201247

Reference yield: 63.0%

(6-bromo-7-methoxybenzo[d][1,3] dioxol-5-yl-)methanol (1192659-02-1) + 3,4,5-trimethoxyphenylboronic Acid (182163-96-8) → [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol (870094-81-8)

Guidance literature:

With potassium phosphate; palladium diacetate; CyJohnPhos; In toluene; at 80 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201201247

upstream raw materials:

7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester

methyl-6-bromo-7-methoxybenzo [d] [1, 3] dioxole-5-carboxylate

3,4,5-trimethoxyphenylboronic Acid

(6-bromo-7-methoxybenzo[d][1,3] dioxol-5-yl-)methanol

Downstream raw materials:

7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde

5-[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]-4-methyl-5H-furan-2-one

eupomatilone-3

(-)-eupomatilone 1