2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one

Base Information

• Chemical Name: 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one
• CAS No.: 1022632-70-7
• Molecular Formula: C₁₁H₉ClF₃NOS
• Molecular Weight: 295.713
• Mol file: 1022632-70-7.mol

Synonyms:2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one

Chemical Property of 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one

There total 1 articles about 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

trifluoroethylamine (753-90-2) + m-Chlorobenzaldehyde (587-04-2) + ethyl 2-sulfanylacetate (623-51-8) → 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (1022632-70-7)

Guidance literature:

With benzoic acid; at 70 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2013.04.002

Reference yield: 77.0%

2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (1022632-70-7) → 2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-thione (1433596-73-6)

Guidance literature:

With Lawessons reagent; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2013.04.002

Reference yield:

2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-one (1022632-70-7) → 5-(3-chlorophenyl)-3-(4-fluorophenyl)-2-methyl-6-(2,2,2-trifluoroethyl)-3a,5-dihydro-3H-pyrazolo[3,4-d]thiazole

Guidance literature:

Multi-step reaction with 2 steps

1.1: Lawessons reagent / 1,4-dioxane / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / toluene / 20 °C / Inert atmosphere; Molecular sieve

2.2: 65 °C / Inert atmosphere

With Lawessons reagent; potassium tert-butylate; In 1,4-dioxane; toluene;

DOI:10.1016/j.tet.2013.04.002

upstream raw materials:

trifluoroethylamine

m-Chlorobenzaldehyde

ethyl 2-sulfanylacetate

Downstream raw materials:

2-(3-chlorophenyl)-3-(2,2,2-trifluoroethyl)thiazolidin-4-thione