753-90-2Relevant articles and documents
METHOD FOR MANUFACTURE OF 1,1,1-TRIFLUORO-2-CHLOROETHANE (HCFC 133A) AND/OR TRFLUOROETHYLAMINE (TFEA)
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Page/Page column 28, (2020/06/05)
A method for manufacture of 1, 1, 1-trifluoro-2-chloroethane (HCFC-133a) and/or trifluoroethylamine (TFEA), wherein at least one reaction step takes place in a microreactor that is comprising or is made of SiC-microreactor, the processes can be efficiently combined in that HCFC-133a produced by using a microreactor, may preferably advantageously serve as starting material and/or intermediate material in the manufacture of TFEA. The HCFC-133a and/or the TFEA can be easily, by a method with only low energy consumption, purified and/or isolated, and preferably the process for purifying and/or isolating does not require a distillation. Advantageously, the separation from excess hydrogen fluoride (HF) and catalyst can easily take place in an energy-saving manner by phase separation.
Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation
Augurusa, Alessandra,Mehta, Meera,Perez, Manuel,Zhu, Jiangtao,Stephan, Douglas W.
supporting information, p. 12195 - 12198 (2016/10/21)
A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.
N-methylimidazole promotes the reaction of homophthalic anhydride with imines
Liu, Jian,Wang, Zheng,Levin, Aaron,Emge, Thomas J.,Rablen, Paul R.,Floyd, David M.,Knapp, Spencer
supporting information, p. 7593 - 7599 (2014/09/16)
The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationalizes the role of NMI is proposed, and a gram-scale procedure for the synthesis and resolution of 10 is also described.