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753-90-2

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753-90-2 Usage

Chemical Properties

clear colorless liquid

Uses

Different sources of media describe the Uses of 753-90-2 differently. You can refer to the following data:
1. 2,2,2-Trifluoroethanamine is a reagent used in chemical synthesis.
2. 2,2,2-Trifluoroethylamine was used in the determination of ibuprofen (2-(p-isobutylphenyl)propionic acid), a non-steroid anti-inflammatory drug (NSAID) residue in surface and wastewater samples.

Synthesis Reference(s)

Canadian Journal of Chemistry, 32, p. 639, 1954 DOI: 10.1139/v54-083

General Description

2,2,2-Trifluoroethylamine, a volatile organic compound, was tested using corona discharge ion mobility spectrometry with orthogonal acceleration time of flight mass spectrometry (CD IMS-oaTOF).

Safety Profile

Low toxicity by inhalation.Corrosive. Highly flammable liquid. When heated todecomposition it emits very toxic fumes of F?? and NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 753-90-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,5 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 753-90:
(5*7)+(4*5)+(3*3)+(2*9)+(1*0)=82
82 % 10 = 2
So 753-90-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H2F4/c1-2(4)3(5,6)7/h1H2

753-90-2 Well-known Company Product Price

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  • Alfa Aesar

  • (B20789)  2,2,2-Trifluoroethylamine, 98%   

  • 753-90-2

  • 1g

  • 509.0CNY

  • Detail
  • Alfa Aesar

  • (B20789)  2,2,2-Trifluoroethylamine, 98%   

  • 753-90-2

  • 5g

  • 2025.0CNY

  • Detail
  • Alfa Aesar

  • (B20789)  2,2,2-Trifluoroethylamine, 98%   

  • 753-90-2

  • 25g

  • 5208.0CNY

  • Detail

753-90-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2,2-Trifluoroethylamine

1.2 Other means of identification

Product number -
Other names Ethanamine, 2,2,2-trifluoro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:753-90-2 SDS

753-90-2Synthetic route

1,1,1-trifluoro-2-chloroethane
75-88-7

1,1,1-trifluoro-2-chloroethane

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With dmap; ammonia at 110℃; Temperature;94%
With ammonia; water at 190℃;
With ammonia; water at 185℃;
trifluoroacetonitrile
353-85-5

trifluoroacetonitrile

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

bis(2,2,2-trifluoroethyl)amine
407-01-2

bis(2,2,2-trifluoroethyl)amine

Conditions
ConditionsYield
With hydrogen; palladium/alumina at 50-60°C; product isolated as CF3CH2NH2*HCl;A 83%
B 17%
With H2; palladium/alumina at 50-60°C; product isolated as CF3CH2NH2*HCl;A 83%
B 17%
1-Chlor-tetrafluor-1-nitro-aethan
2261-27-0

1-Chlor-tetrafluor-1-nitro-aethan

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With hydrogen at 60-80°C 80 atm;29%
With H2; catalyst: Pd-activated carbon at 60-80°C 80 atm;29%
nitro pentafluoroethane
354-81-4

nitro pentafluoroethane

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With hydrogen at 60-80°C 80 atm;10%
With H2; catalyst: Pd-activated carbon at 60-80°C 80 atm;10%
2-bromo-1,1,1-trifluoroethane
421-06-7

2-bromo-1,1,1-trifluoroethane

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With ammonia; sodium iodide at 140℃;
With ammonia; water at 190℃;
trifluoroacetonitrile
353-85-5

trifluoroacetonitrile

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With diethyl ether; platinum at 20 - 60℃; Hydrogenation.unter Druck;
With H2; platinum(IV) oxide at 50-60°C; product isolated as CF3CH2NH2*HCl;
3,3,3-trifluoropropionamide
460-75-3

3,3,3-trifluoropropionamide

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

2,3-dibromo-3,3-difluoro-propionic acid bromoamide
432-74-6

2,3-dibromo-3,3-difluoro-propionic acid bromoamide

Conditions
ConditionsYield
With potassium hydroxide; bromine
2,2,2-trifluoroacetamide
354-38-1

2,2,2-trifluoroacetamide

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
With sodium borate; 1,2-dimethoxyethane; boron fluoride ether
With Hexamethyldisiloxane; [(SIMes)PFMe2][B(C6F5)4]2 at 100℃; for 5h; Inert atmosphere; Schlenk technique; Glovebox;
With tetrahydrofuran; lithium aluminium tetrahydride
1,1,1-trifluoro-2-nitroethane
819-07-8

1,1,1-trifluoro-2-nitroethane

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With hydrogenchloride; iron
[2-Methyl-prop-(E)-ylidene]-(2,2,2-trifluoro-ethyl)-amine
22483-17-6

[2-Methyl-prop-(E)-ylidene]-(2,2,2-trifluoro-ethyl)-amine

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
In water at 35℃; Equilibrium constant;
N-acetyl-2,2,2-trifluoroethylamine
34242-99-4

N-acetyl-2,2,2-trifluoroethylamine

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 30℃; Rate constant; hydrolysis;
(trifluoroethyl)ammonium ion
54930-25-5

(trifluoroethyl)ammonium ion

ethylamine
75-04-7

ethylamine

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

ethylammonium
16999-99-8

ethylammonium

Conditions
ConditionsYield
Thermodynamic data; ΔHdeg, ΔGdeg;
(2,2,2-Trifluoro-ethyl)-thiocarbamic acid; compound with triethyl-amine

(2,2,2-Trifluoro-ethyl)-thiocarbamic acid; compound with triethyl-amine

A

carbon oxide sulfide
463-58-1

carbon oxide sulfide

B

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With cacodylate buffer In water at 25℃; Mechanism; Rate constant; general acid catalysis, other reagent (phosphate buffer), pH 6.16 - pH 6.36;
C3H3F3NS2(1-)*K(1+)

C3H3F3NS2(1-)*K(1+)

A

carbon disulfide
75-15-0

carbon disulfide

B

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With acetate buffer (10percent HA, 0.1 M, pH 5.55) In water at 25℃; Rate constant;
(1S,2R,4R,6S)-6-Hydroxy-bicyclo[2.2.1]heptane-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide
74158-01-3

(1S,2R,4R,6S)-6-Hydroxy-bicyclo[2.2.1]heptane-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

A

trifluoroethylamine
753-90-2

trifluoroethylamine

endo-6-hydroxybicyclo<2.2.1>heptane-endo-2-carboxylic acid lactone
6712-12-5

endo-6-hydroxybicyclo<2.2.1>heptane-endo-2-carboxylic acid lactone

Conditions
ConditionsYield
In methanol; water at 30℃; Rate constant;
In water at 30℃; Rate constant; effect of the basicity of catalyst;
(1R,2S,3R,4S)-3-(2,2,2-Trifluoro-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
93630-45-6

(1R,2S,3R,4S)-3-(2,2,2-Trifluoro-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
129-64-6

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

Conditions
ConditionsYield
With water at 38℃; Rate constant;
(1R,7S)-5-Hydroxy-5-(2,2,2-trifluoro-ethylamino)-4-oxa-tricyclo[5.2.1.02,6]dec-8-en-3-one

(1R,7S)-5-Hydroxy-5-(2,2,2-trifluoro-ethylamino)-4-oxa-tricyclo[5.2.1.02,6]dec-8-en-3-one

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
129-64-6

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

Conditions
ConditionsYield
With water at 38℃; Rate constant;
S,S-dimethyl-N-(2,2,2-trifluoroethyl)sulfiliminium chloride

S,S-dimethyl-N-(2,2,2-trifluoroethyl)sulfiliminium chloride

A

dimethylsulfide
75-18-3

dimethylsulfide

B

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With iodide; hydrogen cation In water at 25℃; Rate constant; Mechanism; ionic strength 1.0 with KCl; solvent deuterium isotope effect; catalytic constants for buffer catalysis;
(2,2,2-Trifluoro-ethyl)-dithiocarbamic acid

(2,2,2-Trifluoro-ethyl)-dithiocarbamic acid

A

carbon disulfide
75-15-0

carbon disulfide

B

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With buffer In water at 25℃; Rate constant; Mechanism;
diethyl ether
60-29-7

diethyl ether

trifluoroacetonitrile
353-85-5

trifluoroacetonitrile

platinum oxide

platinum oxide

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
at 50 - 60℃; unter Druck.Hydrogenation;
3,3,3-trifluoropropionamide
460-75-3

3,3,3-trifluoropropionamide

bromine
7726-95-6

bromine

aqueous KOH-solution

aqueous KOH-solution

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

2,3-dibromo-3,3-difluoro-propionic acid bromoamide
432-74-6

2,3-dibromo-3,3-difluoro-propionic acid bromoamide

N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl bromide

N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl bromide

A

trifluoroethylamine
753-90-2

trifluoroethylamine

B

(E)-N-(2,2,2-trifluoroethylidene)-4-methoxyaniline
177838-10-7

(E)-N-(2,2,2-trifluoroethylidene)-4-methoxyaniline

Conditions
ConditionsYield
With lithium tri(t-butoxy)aluminum hydride In tetrahydrofuran at 20℃; for 0.5h;A n/a
B 38 % Spectr.
(carboxymehyl)(2,2,2-trifluoroethylamine)cobaloxime
81956-65-2

(carboxymehyl)(2,2,2-trifluoroethylamine)cobaloxime

A

trifluoroethylamine
753-90-2

trifluoroethylamine

(carboxymethyl)aquocobaloxime
60193-28-4

(carboxymethyl)aquocobaloxime

Conditions
ConditionsYield
With KCl; H2O In water Kinetics; 25°C; not isolated, detected spectrophotometrically;
Co((CCH3NO)2H)2(CH2COO)CF3CH2NH2(1-)
757895-36-6

Co((CCH3NO)2H)2(CH2COO)CF3CH2NH2(1-)

A

trifluoroethylamine
753-90-2

trifluoroethylamine

Co((CCH3NO)2H)2(CH2COO)H2O(1-)
778519-97-4

Co((CCH3NO)2H)2(CH2COO)H2O(1-)

Conditions
ConditionsYield
With KCl; H2O In water Kinetics; 25°C; not isolated, detected spectrophotometrically;
benzylidene-(2,2,2-trifluoro-ethyl)-amine

benzylidene-(2,2,2-trifluoro-ethyl)-amine

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
Hydrolysis;
N-chloro-2,2,2-trifluoroethylamine
1252686-20-6

N-chloro-2,2,2-trifluoroethylamine

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With sodium perchlorate; iodide In water at 25℃; pH=6.5; Kinetics; Reagent/catalyst; Solvent; pH-value; aq. phosphate buffer;
C55H77CoF3N6O14(1+)

C55H77CoF3N6O14(1+)

water
7732-18-5

water

A

aquacyanocob(III)yrinic acid heptamethyl ester

aquacyanocob(III)yrinic acid heptamethyl ester

B

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
In aq. phosphate buffer at 25℃; pH=6.8; Equilibrium constant;
2,2,2-trifluroethylamine hydrochloride
373-88-6

2,2,2-trifluroethylamine hydrochloride

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
With sodium hydroxide In water
With sodium hydroxide In dichloromethane-d2 for 0.166667h; Inert atmosphere;
2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

trifluoroethylamine
753-90-2

trifluoroethylamine

Conditions
ConditionsYield
Stage #1: 2,2,2-Trifluoroacetaldehyde With ammonium hydroxide; formic acid at 25℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride at 5℃; for 1.33333h; Inert atmosphere;
trifluoroethylamine
753-90-2

trifluoroethylamine

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate
112811-68-4

ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester
874482-36-7

3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Conditions
ConditionsYield
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux;
Stage #2: trifluoroethylamine In ethanol at 0 - 20℃;
100%
Stage #1: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate With acetic anhydride for 2h; Heating / reflux;
Stage #2: trifluoroethylamine In ethanol at 0 - 20℃;
trifluoroethylamine
753-90-2

trifluoroethylamine

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

3-amino-5-bromobenzoic acid methyl ester
706791-83-5

3-amino-5-bromobenzoic acid methyl ester

C11H10BrF3N2O3
1251863-84-9

C11H10BrF3N2O3

Conditions
ConditionsYield
Stage #1: 4-Nitrophenyl chloroformate; 3-amino-5-bromobenzoic acid methyl ester In tetrahydrofuran at 60℃; for 1h;
Stage #2: trifluoroethylamine With diisopropylamine In tetrahydrofuran at 60℃; for 2h;
100%
3-bromo-5-(1,3-dioxolan-2-yl)aniline
936844-19-8

3-bromo-5-(1,3-dioxolan-2-yl)aniline

trifluoroethylamine
753-90-2

trifluoroethylamine

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

C12H12BrF3N2O3
1251863-68-9

C12H12BrF3N2O3

Conditions
ConditionsYield
Stage #1: 3-bromo-5-(1,3-dioxolan-2-yl)aniline; 4-Nitrophenyl chloroformate In tetrahydrofuran at 60℃; for 1h;
Stage #2: trifluoroethylamine With diisopropylamine In tetrahydrofuran at 20 - 60℃;
100%
trifluoroethylamine
753-90-2

trifluoroethylamine

tert butyl 4-formylpiperidine-1-carboxylate
137076-22-3

tert butyl 4-formylpiperidine-1-carboxylate

tert-butyl 4-((2,2,2-trifluoroethylamino)methyl)piperidine-1-carboxylate
1357923-39-7

tert-butyl 4-((2,2,2-trifluoroethylamino)methyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: trifluoroethylamine; tert butyl 4-formylpiperidine-1-carboxylate In dichloromethane; acetic acid at 20℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane; acetic acid at 20℃; for 16h;
Stage #3: With sodium hydroxide In dichloromethane; acetic acid pH=10;
100%
trifluoroethylamine
753-90-2

trifluoroethylamine

4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

4-fluoro-N-(2,2,2-trifluoroethyl)benzenesulfonamide
1156374-08-1

4-fluoro-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine at 20℃; for 12h;100%
trifluoroethylamine
753-90-2

trifluoroethylamine

2-chloro-1,4-dimethoxybenzene
2100-42-7

2-chloro-1,4-dimethoxybenzene

C10H12F3NO2

C10H12F3NO2

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
trifluoroethylamine
753-90-2

trifluoroethylamine

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3,5-difluoro-N-(2,2,2-trifluoroethyl)aniline

3,5-difluoro-N-(2,2,2-trifluoroethyl)aniline

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

trifluoroethylamine
753-90-2

trifluoroethylamine

C9H9F3N2O2

C9H9F3N2O2

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
5-bromopyrimidine
4595-59-9

5-bromopyrimidine

trifluoroethylamine
753-90-2

trifluoroethylamine

C6H6F3N3

C6H6F3N3

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
trifluoroethylamine
753-90-2

trifluoroethylamine

5-bromo-indole-1-carboxylic acid tert-butyl ester
182344-70-3

5-bromo-indole-1-carboxylic acid tert-butyl ester

C15H17F3N2O2

C15H17F3N2O2

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
trifluoroethylamine
753-90-2

trifluoroethylamine

2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

2-methyl-N-(2,2,2-trifluoroethyl)aniline
62351-54-6

2-methyl-N-(2,2,2-trifluoroethyl)aniline

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Time; Reagent/catalyst; Sealed tube; Inert atmosphere;100%
2,3-Dimethylmaleic anhydride
766-39-2

2,3-Dimethylmaleic anhydride

trifluoroethylamine
753-90-2

trifluoroethylamine

3,4-dimethyl-1-(2,2,2-trifluoroethyl)pyrrole-2,5-dione

3,4-dimethyl-1-(2,2,2-trifluoroethyl)pyrrole-2,5-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene Reflux;100%
trifluoroethylamine
753-90-2

trifluoroethylamine

2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid
180386-35-0

2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid

tert-butyl 4-oxo-3-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

tert-butyl 4-oxo-3-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Conditions
ConditionsYield
Stage #1: 2-(8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane for 0.5h;
Stage #2: trifluoroethylamine In dichloromethane at 20℃; Inert atmosphere;
100%
trifluoroethylamine
753-90-2

trifluoroethylamine

1-iodo-5-methoxy-phenylamine
62605-98-5

1-iodo-5-methoxy-phenylamine

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

C10H10F3IN2O2
1251863-61-2

C10H10F3IN2O2

Conditions
ConditionsYield
Stage #1: 1-iodo-5-methoxy-phenylamine; 4-Nitrophenyl chloroformate In tetrahydrofuran at 60℃; for 1h;
Stage #2: trifluoroethylamine With triethylamine In tetrahydrofuran at 20 - 60℃;
99.9%
6,8-dibromo-7-methoxy-3-hydroximino-3,4-dihydrocoumarin
914222-80-3

6,8-dibromo-7-methoxy-3-hydroximino-3,4-dihydrocoumarin

trifluoroethylamine
753-90-2

trifluoroethylamine

N-(2,2,2-trifluoroethyl) 3-(3,5-dibromo-2-hydroxy-4-methoxyphenyl)-2(E)-(hydroximino)propanamide

N-(2,2,2-trifluoroethyl) 3-(3,5-dibromo-2-hydroxy-4-methoxyphenyl)-2(E)-(hydroximino)propanamide

Conditions
ConditionsYield
Heating;99%
C44H43BrN4O5

C44H43BrN4O5

trifluoroethylamine
753-90-2

trifluoroethylamine

C46H46F3N5O5

C46H46F3N5O5

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 72h;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

5-sec-butyl-4,6-dibromo-2-methylthiopyrimidine
944740-38-9

5-sec-butyl-4,6-dibromo-2-methylthiopyrimidine

6-bromo-5-sec-butyl-2-methylthio-N-(2,2,2-trifluoroethyl)pyrimidine-4-amine
944740-39-0

6-bromo-5-sec-butyl-2-methylthio-N-(2,2,2-trifluoroethyl)pyrimidine-4-amine

Conditions
ConditionsYield
In 1,3-dimethyl-2-imidazolidinone at 120℃; for 10h;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

allyl L-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)thioureido)pentanoate
1060769-19-8

allyl L-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)thioureido)pentanoate

allyl L-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(2-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)-3-(2,2,2-trifluoroethyl)guanidino)pentanoate
1060769-27-8

allyl L-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(2-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)-3-(2,2,2-trifluoroethyl)guanidino)pentanoate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0833333h;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester
1159600-11-9

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide
1159600-12-0

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,2-trifluoro-ethyl)-nicotinamide

Conditions
ConditionsYield
Stage #1: trifluoroethylamine With trimethylaluminum In 1,4-dioxane; toluene at 20℃; for 1h;
Stage #2: 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester In 1,4-dioxane; toluene at 85 - 95℃; for 2h;
99%
Stage #1: trifluoroethylamine With trimethylaluminum In 1,4-dioxane; toluene at 20℃; for 1h;
Stage #2: 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester In 1,4-dioxane; toluene at 85 - 95℃; for 2h;
99%
Stage #1: trifluoroethylamine With trimethylaluminum In 1,4-dioxane; toluene at 20℃; for 1h;
Stage #2: 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester In 1,4-dioxane; toluene at 85 - 95℃; for 2h;
99%
trifluoroethylamine
753-90-2

trifluoroethylamine

6-(4-fluoro-phenyl)-2-methylsulfanyl-pteridin-4-ol
1000885-55-1

6-(4-fluoro-phenyl)-2-methylsulfanyl-pteridin-4-ol

[6-(4-fluoro-phenyl)-2-methylsulfanyl-pteridin-4-yl]-(2,2,2-trifluoro-ethyl)-amine
1000885-56-2

[6-(4-fluoro-phenyl)-2-methylsulfanyl-pteridin-4-yl]-(2,2,2-trifluoro-ethyl)-amine

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

(3R,4R,5S)-ethyl 4-acetamido-5-(3-((benzyloxy)carbonyl)thioureido)-3-(pentan-3-yloxy)-cyclohex-1-enecarboxylate
1588477-08-0

(3R,4R,5S)-ethyl 4-acetamido-5-(3-((benzyloxy)carbonyl)thioureido)-3-(pentan-3-yloxy)-cyclohex-1-enecarboxylate

ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
1588477-15-9

ethyl (3R,4R,5S)-4-acetamido-5-(1-(benzyloxycarbonyl)-2-(2,2,2-trifluoroethyl)guanidino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;99%
6-bromoquinoxaline
50998-17-9

6-bromoquinoxaline

trifluoroethylamine
753-90-2

trifluoroethylamine

C10H8F3N3

C10H8F3N3

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;99%
5-bromo-2-methylbenzothiazole
63837-11-6

5-bromo-2-methylbenzothiazole

trifluoroethylamine
753-90-2

trifluoroethylamine

2-methyl-N-(2,2,2-trifluoroethyl)benzo[d]thiazol-5-amine

2-methyl-N-(2,2,2-trifluoroethyl)benzo[d]thiazol-5-amine

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

(4-bromo-phenyl)butylamine
81100-29-0

(4-bromo-phenyl)butylamine

C12H17F3N2

C12H17F3N2

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Reagent/catalyst; Time; Sealed tube; Inert atmosphere;99%
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

trifluoroethylamine
753-90-2

trifluoroethylamine

N-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)aniline

N-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)aniline

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Reagent/catalyst; Time; Sealed tube; Inert atmosphere;99%
3-Bromopyridine
626-55-1

3-Bromopyridine

trifluoroethylamine
753-90-2

trifluoroethylamine

m-<(Trifluoroethyl)amino>pyridine
77262-40-9

m-<(Trifluoroethyl)amino>pyridine

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;99%
With copper(I) oxide; C19H24N2O7; potassium carbonate In methanol at 120℃; for 24h; Ullmann Condensation;81%
trifluoroethylamine
753-90-2

trifluoroethylamine

propynoic acid ethyl ester
623-47-2

propynoic acid ethyl ester

5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester
129768-30-5, 948551-04-0

5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: trifluoroethylamine With tert.-butylnitrite; acetic acid In dichloromethane at 60℃; for 0.0833333h; Flow reactor;
Stage #2: propynoic acid ethyl ester In dichloromethane at 90℃; for 0.166667h; Flow reactor;
99%
trifluoroethylamine
753-90-2

trifluoroethylamine

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

3-trifluoromethyl-1H-pyrazole-5-carboxylic acid methyl ester
6833-82-5

3-trifluoromethyl-1H-pyrazole-5-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: trifluoroethylamine With tert.-butylnitrite; acetic acid In dichloromethane at 60℃; for 0.0833333h; Flow reactor;
Stage #2: propynoic acid methyl ester In dichloromethane at 90℃; for 0.166667h; Flow reactor;
99%
trifluoroethylamine
753-90-2

trifluoroethylamine

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 3-(trifluoromethyl)-1H-pyrazole-4,5-di-carboxylate

dimethyl 3-(trifluoromethyl)-1H-pyrazole-4,5-di-carboxylate

Conditions
ConditionsYield
Stage #1: trifluoroethylamine With tert.-butylnitrite; acetic acid In dichloromethane at 60℃; for 0.0833333h; Flow reactor;
Stage #2: dimethyl acetylenedicarboxylate In dichloromethane at 90℃; for 0.166667h; Flow reactor;
99%
trifluoroethylamine
753-90-2

trifluoroethylamine

tert-butyl 10,10-dimethyl-3'-oxo-3,6-bis(((trifluoromethyl)sulfonyl)oxy)-3’H,10H-spiro[anthracene-9,1'-isobenzofuran]-6'-carboxylate

tert-butyl 10,10-dimethyl-3'-oxo-3,6-bis(((trifluoromethyl)sulfonyl)oxy)-3’H,10H-spiro[anthracene-9,1'-isobenzofuran]-6'-carboxylate

C32H30F6N2O4

C32H30F6N2O4

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; XPhos In toluene at 120℃; for 1.5h; Microwave irradiation; Inert atmosphere; Schlenk technique;99%

753-90-2Relevant articles and documents

METHOD FOR MANUFACTURE OF 1,1,1-TRIFLUORO-2-CHLOROETHANE (HCFC 133A) AND/OR TRFLUOROETHYLAMINE (TFEA)

-

Page/Page column 28, (2020/06/05)

A method for manufacture of 1, 1, 1-trifluoro-2-chloroethane (HCFC-133a) and/or trifluoroethylamine (TFEA), wherein at least one reaction step takes place in a microreactor that is comprising or is made of SiC-microreactor, the processes can be efficiently combined in that HCFC-133a produced by using a microreactor, may preferably advantageously serve as starting material and/or intermediate material in the manufacture of TFEA. The HCFC-133a and/or the TFEA can be easily, by a method with only low energy consumption, purified and/or isolated, and preferably the process for purifying and/or isolating does not require a distillation. Advantageously, the separation from excess hydrogen fluoride (HF) and catalyst can easily take place in an energy-saving manner by phase separation.

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

Augurusa, Alessandra,Mehta, Meera,Perez, Manuel,Zhu, Jiangtao,Stephan, Douglas W.

supporting information, p. 12195 - 12198 (2016/10/21)

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

N-methylimidazole promotes the reaction of homophthalic anhydride with imines

Liu, Jian,Wang, Zheng,Levin, Aaron,Emge, Thomas J.,Rablen, Paul R.,Floyd, David M.,Knapp, Spencer

supporting information, p. 7593 - 7599 (2014/09/16)

The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationalizes the role of NMI is proposed, and a gram-scale procedure for the synthesis and resolution of 10 is also described.

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