N-tetradecanoyl-L-tyrosine methyl ester

Base Information

• Chemical Name: N-tetradecanoyl-L-tyrosine methyl ester
• CAS No.: 1052696-20-4
• Molecular Formula: C₂₄H₃₉NO₄
• Molecular Weight: 405.578
• Mol file: 1052696-20-4.mol

Synonyms:N-tetradecanoyl-L-tyrosine methyl ester

Chemical Property of N-tetradecanoyl-L-tyrosine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tetradecanoyl-L-tyrosine methyl ester

There total 2 articles about N-tetradecanoyl-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

L-Tyr-OMe (1080-06-4) + n-tetradecanoic acid (544-63-8) → N-tetradecanoyl-L-tyrosine methyl ester (1052696-20-4)

Guidance literature:

n-tetradecanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.333333h; Cooling with ice;

L-Tyr-OMe; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1007/s12039-017-1298-y

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N-tetradecanoyl-L-tyrosine methyl ester (1052696-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / Cooling with ice

2.2: 12 h / 20 °C

With sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1007/s12039-017-1298-y

Reference yield: 96.0%

N-tetradecanoyl-L-tyrosine methyl ester (1052696-20-4) → (S)-3-(4-hydroxyphenyl )-2-tetradecanamidopropanoic acid

Guidance literature:

N-tetradecanoyl-L-tyrosine methyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water;

DOI:10.1007/s12039-017-1298-y

upstream raw materials:

L-Tyr-OMe

n-tetradecanoic acid

L-tyrosine