(3-benzyloxy-3',4'-diphenyl)diphenylacetylene

Base Information

Chemical Name:(3-benzyloxy-3',4'-diphenyl)diphenylacetylene
CAS No.:1356496-95-1
Molecular Formula:C₃₃H₂₄O
Molecular Weight:436.553
Hs Code.:

Synonyms:(3-benzyloxy-3',4'-diphenyl)diphenylacetylene

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Chemical Property of (3-benzyloxy-3',4'-diphenyl)diphenylacetylene

Chemical Property:

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Technology Process of (3-benzyloxy-3',4'-diphenyl)diphenylacetylene

There total 7 articles about (3-benzyloxy-3',4'-diphenyl)diphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 128133-59-5
1-ethynyl-3-(phenylmethoxy)benzene

: 76129-21-0
4-iodo-1,2-diphenylbenzene

: 1356496-95-1
(3-benzyloxy-3',4'-diphenyl)diphenylacetylene

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1002/anie.201106706

Reference yield:

: 1356497-05-6
(3,4-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

: 1356496-95-1
(3-benzyloxy-3',4'-diphenyl)diphenylacetylene

Guidance literature:: Multi-step reaction with 3 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; caesium carbonate / 1,2-dimethoxyethane / 40.5 h / 80 °C

2: Iodine monochloride / dichloromethane / 2 h / 0 °C

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; Iodine monochloride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1: Suzuki coupling / 3: Sonogashira coupling;
DOI:10.1002/anie.201106706

Reference yield:

: 120-83-2,40477-79-0
2,4-dichlorophenol

: 1356496-95-1
(3-benzyloxy-3',4'-diphenyl)diphenylacetylene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2.5 h / 90 °C

2.1: sodium / toluene / 19 h / Reflux

3.1: n-butyllithium / diethyl ether; hexane / 20 h / 0 °C

3.2: 4 h / 0 - 20 °C

4.1: potassium fluoride; C₅₆H₅₁CuO₂P₃; 18-crown-6 ether / monoethylene glycol diethyl ether / 22 h / 100 °C / Inert atmosphere

5.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; caesium carbonate / 1,2-dimethoxyethane / 40.5 h / 80 °C

6.1: Iodine monochloride / dichloromethane / 2 h / 0 °C

7.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 18-crown-6 ether; C₅₆H₅₁CuO₂P₃; water; sodium; Iodine monochloride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; monoethylene glycol diethyl ether; toluene; 5.1: Suzuki coupling / 7.1: Sonogashira coupling;
DOI:10.1002/anie.201106706