128133-59-5

Basic information

• Product Name: 1-(BENZYLOXY)-3-ETHYNYLBENZENE
• Synonyms: 1-(BENZYLOXY)-3-ETHYNYLBENZENE;Benzene, 1-ethynyl-3-(phenylMethoxy)-;1-Ethynyl-3-(phenylMethoxy)-benzene
• CAS NO: 128133-59-5
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.25518
• Mol File: 128133-59-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 336.6°C at 760 mmHg
• Flash Point: 153.8°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.000217mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 1-(BENZYLOXY)-3-ETHYNYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(BENZYLOXY)-3-ETHYNYLBENZENE(128133-59-5)
• EPA Substance Registry System: 1-(BENZYLOXY)-3-ETHYNYLBENZENE(128133-59-5)

Safety Data

• Hazardous Substances Data: 128133-59-5(Hazardous Substances Data)

Usage

General Description

1-(Benzyloxy)-3-ethynylbenzene is a chemical compound with the molecular formula C16H12O. It is a derivative of benzene with a benzyloxy group (C6H5O-) and an ethynyl group (C2H-). 1-(BENZYLOXY)-3-ETHYNYLBENZENE is used in organic synthesis and is a key intermediate in the production of various organic compounds. It is a colorless liquid at room temperature and is insoluble in water, but soluble in most organic solvents. 1-(Benzyloxy)-3-ethynylbenzene has a wide range of applications in industries such as pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C15H12O/c1-2-13-9-6-10-15(11-13)16-12-14-7-4-3-5-8-14/h1,3-11H,12H2

Upstream product

• 10401-11-3 3-hydroxy phenylacetylene 
• 100-44-7 benzyl chloride 
• 626-02-8 3-Iodophenol 
• 388061-72-1 3-[2-(trimethylsilylethynyl)]phenol 
• 177259-98-2 2-[(3-(benzyloxy)phenyl)]ethan-1-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1618099-63-0 (E)-2-(3-(benzyloxy)styryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1356496-95-1 (3-benzyloxy-3',4'-diphenyl)diphenylacetylene 
• 185994-78-9 methyl 2-{3-[2-(3,4-diphenylphenyl)ethan-1-yl]phenoxy}acetate 
• 185995-59-9 1-(3-hydroxyphenyl)-2-(3,4-diphenylphenyl)ethane 
• 668477-50-7 1-(benzyloxy)-3-ethylbenzene 
• 173098-21-0 1-Ethenyl-3-(phenylmethoxy)benzene 
• 620-18-8 3-hydroxystyrene 
• 1203610-65-4 5-[3-[(phenyl)methoxy]phenyl]-3-isoxazolecarboxylic acid ethyl ester 
• 141976-47-8 1-phenyl-3-(3-benzyloxyphenyl)-2-propyne-1-one 

Relevant articles and documents

Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled D-amino acid oxidase (DAAO) inhibitor for PET imaging

Selective DAAO inhibitors have demonstrated promising therapeutic effects in clinical studies, including clinically alleviating symptoms of schizophrenic patients and ameliorating cognitive function in Alzheimer's patients with early phase. Herein we repo

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp3-sp3 (C-C) bonds to sp-sp (C=C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).

Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. A potent and selective series for further drug development

New antituberculosis (anti-TB) drugs are urgently needed to shorten the 6-12month treatment regimen and especially to battle drug-resistant Mycobacterium tuberculosis (Mtb) strains. In this study, we have continued our efforts to develop isoxazole-based a