[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

Base Information

Chemical Name:[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate
CAS No.:870995-01-0
Molecular Formula:C₂₈H₂₂FN₇O₈
Molecular Weight:603.523
Hs Code.:

[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

Synonyms:[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

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Chemical Property of [(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

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Technology Process of [(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

There total 12 articles about [(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 702681-58-1
(5R)-3-{3-fluoro-4-[6-((5S)-5-(hydroxymethyl)-4,5-dihydroisoxazol-3-yl)pyridin-3-yl]phenyl}-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 7693-46-1
4-Nitrophenyl chloroformate

: 870995-01-0
[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

Guidance literature:: With pyridine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 4h;

Reference yield:

: acetic acid (5R)-3-(3-fluorophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870995-01-0
[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

Guidance literature:: Multi-step reaction with 8 steps

1: iodine; silver trifluoroacetate / chloroform; acetonitrile / 36.5 h / 20 °C

2: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

5: 1,4-dioxane / 100 °C

6: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

7: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 2 h / 75 °C

8: pyridine / DMF (N,N-dimethyl-formamide) / 4 h / 0 - 20 °C

With pyridine; methanol; sodium azide; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 501939-95-3
(5R)-3-(3-fluoro-4-iodophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 870995-01-0
[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl 4-nitrophenylcarbonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 0.67 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 2 h / 75 °C

3: pyridine / DMF (N,N-dimethyl-formamide) / 4 h / 0 - 20 °C

With pyridine; potassium acetate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In DMF (N,N-dimethyl-formamide); water; dimethyl sulfoxide;