C₂₀H₂₁FN₄O₃S

Base Information

• Chemical Name: C₂₀H₂₁FN₄O₃S
• CAS No.: 1443829-61-5
• Molecular Formula: C₂₀H₂₁FN₄O₃S
• Molecular Weight: 416.476
• Mol file: 1443829-61-5.mol

Synonyms:C₂₀H₂₁FN₄O₃S

Chemical Property of C₂₀H₂₁FN₄O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁FN₄O₃S

There total 5 articles about C₂₀H₂₁FN₄O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

C20H22N4O4S (1443745-66-1) → C20H21FN4O3S (1443829-61-5)

Guidance literature:

With diethylamino-sulfur trifluoride; In chloroform; at 0 ℃; for 0.166667h;

Reference yield:

4-methoxy-aniline (104-94-9) → C20H21FN4O3S (1443829-61-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: ammonium acetate; acetic acid / 0.75 h / 120 °C / Microwave irradiation

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 20 °C

3.2: pH 6

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethyl sulfoxide / 16 h / 20 °C

5.1: diethylamino-sulfur trifluoride / chloroform / 0.17 h / 0 °C

With hydrogenchloride; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; ammonium acetate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; ethanol; chloroform; water; dimethyl sulfoxide;

Reference yield:

5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-thieno[3,4-d]pyridazine-1-carboxylic acid (222164-34-3) → C20H21FN4O3S (1443829-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethyl sulfoxide / 16 h / 20 °C

2: diethylamino-sulfur trifluoride / chloroform / 0.17 h / 0 °C

With diethylamino-sulfur trifluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; dimethyl sulfoxide;

upstream raw materials:

5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-thieno[3,4-d]pyridazine-1-carboxylic acid

4-methoxy-aniline

3-oxo-2-(2-(4-methoxyphenyl)hydrazono)butanoic acid ethyl ester

ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate