N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide

Base Information

• Chemical Name: N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide
• CAS No.: 1361330-23-5
• Molecular Formula: C₂₈H₃₁F₂N₅O₄S
• Molecular Weight: 571.648

Synonyms:N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide

Chemical Property of N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide

Chemical Property:

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Technology Process of N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide

There total 6 articles about N₁-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N₂,2-dimethylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H39F2N5O6S → N1-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N2,2-dimethylalaninamide (1361330-23-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

6-fluoro-4-methoxy-1H-indazol-3-amine (1240518-42-6) → N1-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N2,2-dimethylalaninamide (1361330-23-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: pyridine / 18 h / 21 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

2,4-difluoro-6-methoxybenzonitrile (1240518-41-5) → N1-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloy)-1 H-indazol-1-yl]methyl}phenyl)methyl]-N2,2-dimethylalaninamide (1361330-23-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: pyridine / 18 h / 21 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h

5.2: 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

6-fluoro-4-methoxy-1H-indazol-3-amine

3-{[3-amino-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}benzonitrile

2,4-difluoro-6-methoxybenzonitrile

N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

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