N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide
CAS No.:1361330-36-0
Molecular Formula:C₂₃H₁₈F₂N₄O₃S
Molecular Weight:468.484
Hs Code.:

Synonyms:N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

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Chemical Property of N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

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Technology Process of N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

There total 4 articles about N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 90260-13-2
3-fluoro-4-methylbenzene-1-sulfonyl chloride

: 1240518-43-7
3-{[3-amino-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}benzonitrile

: 1361330-36-0
N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

Guidance literature:: With pyridine; at 21 ℃; for 18h; Inert atmosphere;

Reference yield:

: 608515-57-7
2,4-difluoro-6-methoxybenzaldehyde

: 1361330-36-0
N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / 3 h / 110 °C

2.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: pyridine / 18 h / 21 °C / Inert atmosphere

With pyridine; hydrazine hydrate; potassium hydroxide; In water; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 1240518-42-6
6-fluoro-4-methoxy-1H-indazol-3-amine

: 1361330-36-0
N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: pyridine / 18 h / 21 °C / Inert atmosphere

With pyridine; potassium hydroxide; In dimethyl sulfoxide;