Technology Process of 9-(2,6-diethyl-4-methylphenyl)-3-oxaspiro[5.5]undecane-8,10-dione
There total 5 articles about 9-(2,6-diethyl-4-methylphenyl)-3-oxaspiro[5.5]undecane-8,10-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / ethanol; water / 5 h / 5 - 20 °C
2.1: sodium ethanolate / ethanol / 4 h / 20 °C / Heating / reflux
3.1: sodium hydroxide; water / 20 °C
3.2: 2 h / 70 °C / pH 2 - 3
4.1: sodium carbonate / ethanol; water / 0.08 h / 20 °C
4.2: 4.17 h / 5 - 20 °C
5.1: lithium hydroxide / palladium diacetate / 1,2-dimethoxyethane; ethanol; water / 17 - 18 h / 0 - 50 °C
5.2: 0 °C / pH 2 - 3
With
potassium hydroxide; lithium hydroxide; sodium hydroxide; water; sodium ethanolate; sodium carbonate;
palladium diacetate;
In
1,2-dimethoxyethane; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium carbonate / ethanol; water / 0.08 h / 20 °C
1.2: 4.17 h / 5 - 20 °C
2.1: lithium hydroxide / palladium diacetate / 1,2-dimethoxyethane; ethanol; water / 17 - 18 h / 0 - 50 °C
2.2: 0 °C / pH 2 - 3
With
lithium hydroxide; sodium carbonate;
palladium diacetate;
In
1,2-dimethoxyethane; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: lithium hydroxide / palladium diacetate / 1,2-dimethoxyethane; ethanol; water / 17 - 18 h / 0 - 50 °C
2.2: 0 °C / pH 2 - 3
With
lithium hydroxide; n-butyllithium;
palladium diacetate;
In
tetrahydrofuran; hexanes; 1,2-dimethoxyethane; ethanol; water;
