3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline

Base Information

• Chemical Name: 3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline
• CAS No.: 209350-70-9
• Molecular Formula: C₁₉H₁₅ClN₆O
• Molecular Weight: 378.821
• Mol file: 209350-70-9.mol

Synonyms:3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline

Chemical Property of 3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline

There total 2 articles about 3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-(2-phenylacetylhydrazino)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

phenylacetyl chloride (103-80-0) + 3-(3(5)-chloro-1H-pyrazol-5(3)-yl)-2-hydrazinoquinoxaline (209350-67-4) → 3-(3(5)-chloro-1H-pyrazol-5(3)-yl)-2-(2-phenylacetylhydrazino)quinoxaline (209350-70-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; 1) 0 deg C to r.t., 2) r.t., overnight;

DOI:10.1002/(SICI)1521-4184(199805)331:5<163::AID-ARDP163>3.0.CO;2-3

Reference yield:

2-chloro-3-(3-chloro-1H-pyrazol-5-yl)quinoxaline (204654-33-1) → 3-(3(5)-chloro-1H-pyrazol-5(3)-yl)-2-(2-phenylacetylhydrazino)quinoxaline (209350-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / N₂H₄*H₂O / 2 h / 150 °C

2: 49 percent / Et₃N / dimethylformamide / 1) 0 deg C to r.t., 2) r.t., overnight

With hydrazine hydrate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-4184(199805)331:5<163::AID-ARDP163>3.0.CO;2-3

Reference yield: 62.0%

3-(3(5)-chloro-1H-pyrazol-5(3)-yl)-2-(2-phenylacetylhydrazino)quinoxaline (209350-70-9) → 1-Benzyl-4-(5-chloro-2H-pyrazol-3-yl)-[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; for 3h; Heating;

DOI:10.1002/(SICI)1521-4184(199805)331:5<163::AID-ARDP163>3.0.CO;2-3

upstream raw materials:

phenylacetyl chloride

3-(3⁽⁵⁾-chloro-1H-pyrazol-5⁽³⁾-yl)-2-hydrazinoquinoxaline

2-chloro-3-(3-chloro-1H-pyrazol-5-yl)quinoxaline