Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:21881-54-9
Molecular Formula:C19H22 N2 O6
Molecular Weight:374.393
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90176283
Nikkaji Number:J51.298B
ChEMBL ID:CHEMBL1099206
Mol file:21881-54-9.mol

Synonyms:diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Vapor Pressure:1.16E-10mmHg at 25°C
Melting Point:114-115 °C
Boiling Point:513.6°Cat760mmHg
PKA:2.77±0.70(Predicted)
Flash Point:264.4°C
PSA：110.45000
Density:1.226g/cm³
LogP:3.80780
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:374.14778643
Heavy Atom Count:27
Complexity:628

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC=C(C=C2)[N+](=O)[O-])C(=O)OCC)C)C

Technology Process of Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 20 articles about Diethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 141-97-9
ethyl acetoacetate

: 555-16-8
4-nitrobenzaldehdye

: 21881-54-9
2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With ammonium hydroxide; at 70 ℃; for 1.33333h;
DOI:10.1016/j.poly.2019.04.035

Reference yield: 97.0%

: 631-61-8,92206-38-7
ammonium acetate

: 141-97-9
ethyl acetoacetate

: 555-16-8
4-nitrobenzaldehdye

: 21881-54-9
2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With iron supported on copper/Zeolite Socony Mobil-5 nanocatalyst; In water; at 20 ℃; Sonication;
DOI:10.1007/s13738-015-0734-5

Reference yield: 97.0%

: 619-73-8
4-nitrobenzyl chloride

: 141-97-9
ethyl acetoacetate

: 21881-54-9
2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With ammonium hydroxide; hydrogen bromide; dimethyl sulfoxide; In water; at 75 ℃; for 2.53333h;
DOI:10.1016/j.tetlet.2018.10.010