dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Base Information

Chemical Name:dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate
CAS No.:1360583-85-2
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

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Chemical Property of dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

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Technology Process of dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

There total 2 articles about dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 885522-58-7
dimethyl 2-[(1-benzyl-2-methyl-1H-indol-3-yl)methylene]malonate

: 1360583-85-2
dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Guidance literature:: With trimethylsulfoxonium iodide; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.266667h; Inert atmosphere;
DOI:10.1002/chem.201101687

Reference yield:

: 95202-45-2
1-benzyl-2-methyl 1H-indole-3-carboxyaldehyde

: 108-59-8
malonic acid dimethyl ester

: 1360583-85-2
dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / toluene / 4 h / Reflux

2: trimethylsulfoxonium iodide; sodium hydride / dimethyl sulfoxide / 0.27 h / 20 °C / Inert atmosphere

With piperidine; trimethylsulfoxonium iodide; sodium hydride; acetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1002/chem.201101687

Reference yield: 88.0%

: 1360583-85-2
dimethyl 2-(1-benzyl-2-methyl-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate

: dimethyl 2-[2-azido-2-(1-benzyl-2-methyl-1H-indol-3-yl)ethyl]malonate

Guidance literature:: With sodium azide; triethylamine hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 4h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201405551