Technology Process of 1-bromo-2,2-dicyclohexylcyclopropane
There total 3 articles about 1-bromo-2,2-dicyclohexylcyclopropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; ethylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at 25 ℃;
for 11h;
Inert atmosphere;
DOI:10.1021/ol203418u
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / dichloromethane; water / 21 h / 45 °C / Inert atmosphere
2: titanium(IV) isopropylate; ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 11 h / 25 °C / Inert atmosphere
With
titanium(IV) isopropylate; ethylmagnesium bromide; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/ol203418u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 2.75 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 21 h / 45 °C / Inert atmosphere
3.1: titanium(IV) isopropylate; ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 11 h / 25 °C / Inert atmosphere
With
titanium(IV) isopropylate; n-butyllithium; ethylmagnesium bromide; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/ol203418u
