(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one
CAS No.:1321545-30-5
Molecular Formula:C₂₇H₂₇NO₅
Molecular Weight:445.515
Hs Code.:

Synonyms:(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

Suppliers and Price of (R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

There total 4 articles about (R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1135-24-6,537-98-4
3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 1321545-30-5
(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 760.05 Torr / Inert atmosphere

2.1: potassium carbonate / acetone / Inert atmosphere; Reflux

3.1: water; potassium hydroxide / methanol / 70 °C

4.1: triethylamine / tetrahydrofuran / -70 - 0 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -70 °C / Inert atmosphere

5.2: -70 - 0 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; ethyl acetate; acetone;
DOI:10.1055/s-0030-1259982

Reference yield:

: 1135-23-5
3-(4-hydroxy-3-methoxyphenyl)propionic acid

: 1321545-30-5
(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / Inert atmosphere; Reflux

2.1: water; potassium hydroxide / methanol / 70 °C

3.1: triethylamine / tetrahydrofuran / -70 - 0 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / -70 °C / Inert atmosphere

4.2: -70 - 0 °C / Inert atmosphere

With n-butyllithium; water; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; acetone;
DOI:10.1055/s-0030-1259982

Reference yield:

: 30034-49-2
β-(4-benzyloxy-3-methoxyphenyl)propionic acid

: 1321545-30-5
(R)-4-benzyl-3-[3-(4-benzyloxy-3-methoxyphenyl)propanoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / -70 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -70 °C / Inert atmosphere

2.2: -70 - 0 °C / Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane;
DOI:10.1055/s-0030-1259982