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3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid

Base Information Edit
  • Chemical Name:3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid
  • CAS No.:1135-24-6
  • Molecular Formula:C10H10O4
  • Molecular Weight:194.187
  • Hs Code.:DERIVATION
  • DSSTox Substance ID:DTXSID5040673
  • Wikidata:Q51617501
  • Metabolomics Workbench ID:130644
  • ChEMBL ID:CHEMBL3185646
  • Mol file:1135-24-6.mol
3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid

Synonyms:(E/Z)-ferulic acid;3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid;C10H10O4;DTXSID5040673;4-Hydroxy-3-methoxy cinnammic acid;Spectrum_001256;SpecPlus_000547;Spectrum2_001394;Spectrum3_001434;Spectrum4_001897;KBioGR_002459;KBioSS_001736;DivK1c_006643;SPBio_001408;CHEMBL3185646;KBio1_001587;KBio2_001736;KBio2_004304;KBio2_006872;KBio3_002388;3-methoxy4-hydroxy cinnamic acid;4-hydroxyl-3-methoxycinnamic acid;CHEBI:193350;2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2Z)-;3-methoxy-4-hydroxy cinnamic acid;3-methoxy-4-hydroxy-cinnamic acid;4-hydroxy-3-methoxy-cinnamic acid;HMS3655P22;AKOS028109905;NCGC00094889-05;NCI60_002312;SY013625;LS-123655;3-(4-hydroxy-3-methoxyphenyl)-acrylic acid;FT-0601239;FT-0646300;3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid;(E/Z)-Ferulic acid 1000 microg/mL in Acetone;3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid;3- (4-hydroxy-3-methoxyphenyl) -2-propenoic acid;Q51617501;1-Acetate 3,5-Bis(4-chlorobenzoate)-2-deoxy-D-erythro-pentofuranose

Suppliers and Price of 3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Ferulic Acid
  • 20mg
  • $ 255.00
  • TRC
  • Ferulic Acid
  • 50g
  • $ 195.00
  • SynQuest Laboratories
  • 4-Hydroxy-3-methoxycinnamic acid 99%
  • 1 g
  • $ 32.00
  • Sigma-Aldrich
  • 4-Hydroxy-3-methoxycinnamic acid mixture of isomers, analytical reference material
  • 100mg
  • $ 66.90
  • Sigma-Aldrich
  • 4-Hydroxy-3-methoxycinnamic acid for synthesis
  • 25 g
  • $ 74.00
  • Sigma-Aldrich
  • Ferulic Acid Pharmaceutical Secondary Standard; Certified Reference Material
  • 100mg
  • $ 133.00
  • Sigma-Aldrich
  • Ferulic acid European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Ferulic acid United States Pharmacopeia (USP) Reference Standard
  • 25mg
  • $ 353.00
  • Sigma-Aldrich
  • 4-Hydroxy-3-methoxycinnamic acid for synthesis
  • 100 g
  • $ 261.77
  • Medical Isotopes, Inc.
  • Ferulic Acid 98%
  • 20 mg
  • $ 413.00
Total 304 raw suppliers
Chemical Property of 3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid Edit
Chemical Property:
  • Appearance/Colour:Pale Yellow Solid 
  • Vapor Pressure:3.34E-06mmHg at 25°C 
  • Melting Point:168-172 °C(lit.) 
  • Refractive Index:1.5168 (estimate) 
  • Boiling Point:372.3 °C at 760 mmHg 
  • PKA:4.58±0.10(Predicted) 
  • Flash Point:150.5 °C 
  • PSA:66.76000 
  • Density:1.316 g/cm3 
  • LogP:1.49860 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:DMSO (Slightly), Methanol (Slightly) 
  • Water Solubility.:soluble 
  • XLogP3:1.5
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:194.05790880
  • Heavy Atom Count:14
  • Complexity:224
Purity/Quality:

99% *data from raw suppliers

Ferulic Acid *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36-37/39 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:COC1=C(C=CC(=C1)C=CC(=O)O)O
  • Uses It can be used as a food preservative and a kind of organic chemicals. It can be used as the intermediates of cinametic acid. It can also be used as food preservative. It can also be applied to biochemical studies Widely distributed in small amounts in plants. Used as an antioxidant and food preservative antineoplastic, choleretic, food preservative anti-oxidant, anti-inflammatory, sunscreen enhancer ferulic acid is a plant-derived anti-oxidant and free-radical scavenger, it protects the skin against uVB-induced redness. When incorporated into formulas with ascorbic acid and tocopherol, ferulic acid can improve their stability and double the photoprotection capacities offered by the formulation. In clinical studies, ferulic acid exhibits good permeation capacities through the stratum corneum, which can be attributed to its lipophilic properties.
  • Description Ferulic acid is widely found in plants, especially in artichoke, eggplant and corn bran. In addition, it is also present in a variety of Chinese herbal medicines, such as angelica, dome, motherwort, snow ganoderma lucidum and so on.
  • Physical properties Appearance: light yellow crystalline powder. Solubility: slightly soluble in cold water; soluble in hot water, with poor stability in aqueous solution; easily decomposed when encounter light; soluble in ethanol and ethyl acetate; slightly soluble in ether; insoluble in benzene and petroleum ether. Melting point: 170–173?°C.
  • Indications This product is mainly used for the treatment of atherosclerosis, coronary heart disease and ischemic cerebrovascular disease.
  • Clinical Use At present, there are sodium ferulate tablets and ferulic acid injection used in clinic. Sodium ferulate tablets are mainly used for the adjuvant therapy of atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis and other vascular disorders. Ferulic acid can also be used for the treatment of migraine headache and vascular headache. Ferulic acid injection is mainly used for the treatment of ischemic cardiovascular and cerebrovascular disease. In addition, sodium ferulate combined with atorvastatin can be used for the treatment of pulmonary hypertension, diabetic nephropathy and chronic glomerulonephritis in clinic . Ferulic acid is also used in combination with other drugs to treat other diseases.
Technology Process of 3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid

There total 188 articles about 3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With ferulic acid esterase from malted Eleusine coracana; In dimethyl sulfoxide; at 37 ℃; for 1h; pH=7.0; Enzyme kinetics;
DOI:10.1021/jf071918d
Refernces Edit
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