2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

Base Information

Chemical Name:2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid
CAS No.:1444311-47-0
Molecular Formula:C₁₈H₁₆N₂O₄S
Molecular Weight:356.402
Hs Code.:

Synonyms:2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

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Chemical Property of 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

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Technology Process of 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

There total 4 articles about 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1444311-31-2
ethyl 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetate

: 1444311-47-0
2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; at 60 - 80 ℃;
DOI:10.1016/j.ejmech.2013.03.066

Reference yield:

: 4653-08-1
4-oxo-4-thiophen-2-yl-butyric acid

: 1444311-47-0
2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 60 °C

2: potassium hydroxide / ethanol / Reflux

3: potassium carbonate / acetonitrile / Reflux

4: sodium hydroxide; water / 60 - 80 °C

With hydrazine hydrate; water; potassium carbonate; potassium hydroxide; sodium hydroxide; In ethanol; acetonitrile; 2: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2013.03.066

Reference yield:

: 52240-00-3
6-(thien-2-yl)-2,3,4,5-tetrahydropyridazin-3-one

: 1444311-47-0
2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / Reflux

2: potassium carbonate / acetonitrile / Reflux

3: sodium hydroxide; water / 60 - 80 °C

With water; potassium carbonate; potassium hydroxide; sodium hydroxide; In ethanol; acetonitrile; 1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2013.03.066