3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
CAS No.:1408000-66-7
Molecular Formula:C₁₁H₁₁N₃O₂
Molecular Weight:217.227
Hs Code.:

Synonyms:3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Technology Process of 3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

There total 4 articles about 3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1408000-66-7
3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; at -5 - 20 ℃; for 0.166667h;

With sodium azide; In water; for 2h;

Reference yield: 95.0%

: 1408000-68-9
methyl 3-amino-4-cyclopropylbenzoate

: 1408000-66-7
3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With hydrogenchloride; sodium azide; sodium nitrite; In water; at -5 - 20 ℃; for 2.16h;
DOI:10.1021/jm301188x

Reference yield:

: 1408000-55-4
methyl 4-cyclopropyl-3-nitrobenzoate

: 1408000-66-7
3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: methyl 4-cyclopropyl-3-nitrobenzoate; With ammonium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water;

With iron; In tetrahydrofuran; water; for 3h; Reflux;
DOI:10.1021/jm301188x