methyl 3-amino-4-cyclopropylbenzoate

Base Information

• Chemical Name: methyl 3-amino-4-cyclopropylbenzoate
• CAS No.: 1408000-68-9
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 1408000-68-9.mol

Synonyms:methyl 3-amino-4-cyclopropylbenzoate

Chemical Property of methyl 3-amino-4-cyclopropylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-amino-4-cyclopropylbenzoate

There total 2 articles about methyl 3-amino-4-cyclopropylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 4-cyclopropyl-3-nitrobenzoate (1408000-55-4) → methyl 3-amino-4-cyclopropylbenzoate (1408000-68-9)

Guidance literature:

With iron; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; water; for 3h; Reflux;

Reference yield:

methyl 4-bromo-3-nitrobenzoate (2363-16-8) → methyl 3-amino-4-cyclopropylbenzoate (1408000-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 95 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 24 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; potassium carbonate; In ethyl acetate; toluene;

DOI:10.1039/c9ob00892f

Reference yield: 95.0%

methyl 3-amino-4-cyclopropylbenzoate (1408000-68-9) → 3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (1408000-66-7)

Guidance literature:

With hydrogenchloride; sodium azide; sodium nitrite; In water; at -5 - 20 ℃; for 2.16h;

DOI:10.1021/jm301188x

upstream raw materials:

methyl 4-bromo-3-nitrobenzoate

methyl 4-cyclopropyl-3-nitrobenzoate

Downstream raw materials:

3-azido-4-cyclopropyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

methyl 4-cyclopropyl-3-iodobenzoate