(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

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Chemical Name:(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt
CAS No.:1402465-24-0
Molecular Formula:C₂₉H₂₆N₃O₄*K
Molecular Weight:519.641
Hs Code.:

Synonyms:(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

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Chemical Property of (R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

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Technology Process of (R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

There total 6 articles about (R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396007-05-8
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

: 1402465-24-0
(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

Guidance literature:: With potassium hydroxide; In ethanol;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1402465-24-0
(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

2: dmap / dichloromethane / 3 h / 20 °C

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 90 °C

4: potassium hydroxide / ethanol

With sodium hydrogencarbonate; potassium hydroxide; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1402466-05-0
(R)-1-phenylethyl 4-(4-hydroxyphenyl)-1-methyl-1H-pyrazol-5-ylcarbamate

: 1402465-24-0
(R)-1-(4'-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 90 °C

3: potassium hydroxide / ethanol

With sodium hydrogencarbonate; potassium hydroxide; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water;