1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
CAS No.:1396007-05-8
Molecular Formula:C₂₉H₂₇N₃O₄
Molecular Weight:481.551
Hs Code.:

Synonyms:1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

There total 11 articles about 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.5%

: 1396007-02-5
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

: 1396007-05-8
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: With methanol; lithium hydroxide; In tetrahydrofuran; at 30 - 65 ℃; for 5h;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1396007-05-8
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

2: dmap / dichloromethane / 3 h / 20 °C

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 90 °C

With sodium hydrogencarbonate; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1215205-50-7
ethyl 1-(4-bromophenyl)cyclopropane-1-carboxylate

: 1396007-05-8
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 85 °C / Inert atmosphere; Sealed tube

2.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Cooling with acetone-dry ice

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

4.1: palladium diacetate; XPhos; potassium phosphate / toluene; water / 100 °C / Inert atmosphere; Sealed tube

5.1: triethylamine / toluene; dichloromethane / 0.17 h / 90 °C / Sealed tube

5.2: 2 h / 105 °C

6.1: lithium hydroxide; methanol / tetrahydrofuran / 5 h / 30 - 65 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; lithium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;