2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

Base Information

Chemical Name:2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine
CAS No.:1229014-90-7
Molecular Formula:C₂₁H₂₅N₅O₂S
Molecular Weight:411.528
Hs Code.:

Synonyms:2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

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Chemical Property of 2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

Chemical Property:

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Technology Process of 2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

There total 5 articles about 2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1229016-76-5
2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-chloro-3-nitropyridine

: 78-81-9
isobutylamine

: 1229014-90-7
2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

Guidance literature:: In acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1229014-90-7
2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 6 h / 60 - 65 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 5 h / 3000.3 Torr

3: triethylamine / methanol / 24 h / 20 - 30 °C

4: acetonitrile / 4 h / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1229014-90-7
2-[4-(2-isopropylthiazol-4-yl)phenylamino]-6-(isobutylamino)-3-nitropyridine

Guidance literature:: Multi-step reaction with 5 steps

1: copper(ll) bromide / ethyl acetate / 8 h / 60 - 65 °C

2: ethanol / 6 h / 60 - 65 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 5 h / 3000.3 Torr

4: triethylamine / methanol / 24 h / 20 - 30 °C

5: acetonitrile / 4 h / 20 °C

With hydrogen; triethylamine; copper(ll) bromide; palladium 10% on activated carbon; In methanol; ethanol; ethyl acetate; acetonitrile;