5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-
CAS No.:72412-04-5
Molecular Formula:C19H25N5O2
Molecular Weight:355.44
Hs Code.:
DSSTox Substance ID:DTXSID20222707
Nikkaji Number:J70.343E
Mol file:72412-04-5.mol

Synonyms:72412-04-5;BRN 0836990;5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-;N-(1-Benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-5-pyrimidinecarboxamide;DTXSID20222707;C19H25N5O2;LS-134782

Suppliers and Price of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-

Chemical Property:

PSA：86.10000
Density:1.23g/cm³
LogP:1.85590
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:355.20082506
Heavy Atom Count:26
Complexity:436

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=NC=C(C(=N1)OC)C(=O)NC2CCN(CC2)CC3=CC=CC=C3

Technology Process of 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)-

There total 6 articles about 5-Pyrimidinecarboxamide, N-(1-benzyl-4-piperidyl)-4-methoxy-2-(methylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 72412-04-5
4-methoxy-2-methylamino-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / dioxane / 6 h / 110 °C

2: phosphorus oxychloride / 0.5 h / 60 °C

3: 43 percent / sodium / Ambient temperature

4: NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In 1,4-dioxane; methanol; water;

Reference yield:

: 72419-31-9
4-Chloro-2-methylamino-pyrimidine-5-carboxylic acid ethyl ester

: 72412-04-5
4-methoxy-2-methylamino-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 72419-45-5
4-methoxy-2-methylamino-pyrimidine-5-carboxylic acid methyl ester

: 72412-04-5
4-methoxy-2-methylamino-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;