Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate

Base Information

Chemical Name:Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate
CAS No.:72419-31-9
Molecular Formula:C₈H₁₀ClN₃O₂
Molecular Weight:215.639
Hs Code.:
DSSTox Substance ID:DTXSID301211334

Synonyms:Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate;SCHEMBL11363820;DTXSID301211334;72419-31-9

Suppliers and Price of Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:215.0461543
Heavy Atom Count:14
Complexity:203

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1Cl)NC

Technology Process of Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate

There total 1 articles about Ethyl 4-chloro-2-(methylamino)-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 72419-31-9
4-Chloro-2-methylamino-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / dioxane / 6 h / 110 °C

2: phosphorus oxychloride / 0.5 h / 60 °C

With trichlorophosphate; In 1,4-dioxane;

Reference yield:

: 72419-31-9
4-Chloro-2-methylamino-pyrimidine-5-carboxylic acid ethyl ester

: 72412-04-5
4-methoxy-2-methylamino-pyrimidine-5-carboxylic acid 1-benzyl-piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 72419-31-9
4-Chloro-2-methylamino-pyrimidine-5-carboxylic acid ethyl ester

: 84332-25-2
4-Methoxy-2-methylamino-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;