(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

Base Information

Chemical Name:(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine
CAS No.:1384956-11-9
Molecular Formula:C₂₁H₁₆FN₃
Molecular Weight:329.377
Hs Code.:

Synonyms:(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

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Chemical Property of (E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

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Technology Process of (E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

There total 3 articles about (E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1379014-30-8
6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

: 501-65-5
diphenyl acetylene

: 1384956-11-9
(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

Guidance literature:: 6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine; diphenyl acetylene; With trimethylaluminum; In hexane; toluene; for 0.0166667h;

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; triphenylphosphine; In hexane; toluene; for 16h; regioselective reaction; Heating;
DOI:10.1021/ol301606y

Reference yield:

: 915720-54-6
1-(5-fluoropyridin-2-yl)ethan-1-one

: 1384956-11-9
(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / Cooling with ice

2.1: morpholine / 90 - 100 °C

3.1: trimethylaluminum / hexane; toluene / 0.02 h

3.2: 16 h / Heating

With morpholine; trimethylaluminum; In methanol; hexane; toluene;
DOI:10.1021/ol301606y

Reference yield:

: C₁₄H₁₄FN₃O₂S

: 1384956-11-9
(E)-7-(1,2-diphenylvinyl)-6-fluoro-3-methyl-[1,2,3]triazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: morpholine / 90 - 100 °C

2.1: trimethylaluminum / hexane; toluene / 0.02 h

2.2: 16 h / Heating

With morpholine; trimethylaluminum; In hexane; toluene;
DOI:10.1021/ol301606y