methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Base Information

Chemical Name:methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate
CAS No.:1363411-14-6
Molecular Formula:C₁₉H₁₇ClN₂O₂
Molecular Weight:340.809
Hs Code.:

Synonyms:methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

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Chemical Property of methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

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Technology Process of methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

There total 6 articles about methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1242071-55-1
methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate

: 4686-05-9
2-(N-(4-chloroanilino))-2-phenylacetonitrile

: 1363411-27-1
C₁₈H₁₃ClN₂O

: 1363411-14-6
methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 30 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201200642

Reference yield: 71.0%

: 1242071-55-1
methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate

: 4686-05-9
2-(N-(4-chloroanilino))-2-phenylacetonitrile

: 1363411-14-6
methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

: methyl 2-({(4-chlorophenyl)[cyano(phenyl)methyl]amino}methyl)acrylate

: C₈H₁₀O₇

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 30 ℃; for 9h; regioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/ejoc.201200642

Reference yield:

: 100-52-7
benzaldehyde

: 1363411-14-6
methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 0.17 h / 20 °C

2: 0.83 h

3: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile

With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile;
DOI:10.1039/c2ob07112f