methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Base Information

• Chemical Name: methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate
• CAS No.: 1363411-14-6
• Molecular Formula: C₁₉H₁₇ClN₂O₂
• Molecular Weight: 340.809
• Mol file: 1363411-14-6.mol

Synonyms:methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Chemical Property of methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate

There total 6 articles about methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate (1242071-55-1) + 2-(N-(4-chloroanilino))-2-phenylacetonitrile (4686-05-9) → C18H13ClN2O (1363411-27-1) + methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate (1363411-14-6)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 30 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201200642

Reference yield: 71.0%

methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate (1242071-55-1) + 2-(N-(4-chloroanilino))-2-phenylacetonitrile (4686-05-9) → methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate (1363411-14-6) + methyl 2-({(4-chlorophenyl)[cyano(phenyl)methyl]amino}methyl)acrylate + C8H10O7

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 30 ℃; for 9h; regioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/ejoc.201200642

Reference yield:

benzaldehyde (100-52-7) → methyl 4-(4-chlorophenylamino)-4-cyano-2-methylene-4-phenylbutanoate (1363411-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.17 h / 20 °C

2: 0.83 h

3: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile

With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile;

DOI:10.1039/c2ob07112f

upstream raw materials:

methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate

(4-chloro-phenylimino)-phenyl-acetonitrile

benzaldehyde

4-chloro-aniline

Downstream raw materials:

C₁₈H₁₃ClN₂O