2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:184879-01-4
Molecular Formula:C₂₃H₂₆F₃NO₂
Molecular Weight:405.46
Hs Code.:

Synonyms:2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

There total 3 articles about 2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-89-8
4-Isopropylphenol

: 184879-01-4
2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 0 deg C , 1 h, 2.) THF, from 0 deg C to RT

2: 67 percent / aq. NaOH / tetrahydrofuran / Ambient temperature

3: 82 percent / B(OH)3 / xylene / Heating

4: 1.) BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h

With sodium hydroxide; n-butyllithium; boric acid; sodium hydride; In tetrahydrofuran; xylene;
DOI:10.1021/jm950364f

Reference yield:

: 1643-16-9
2-(4-isopropylphenoxy)acetic acid

: 184879-01-4
2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / B(OH)3 / xylene / Heating

2: 1.) BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h

With n-butyllithium; boric acid; In xylene;
DOI:10.1021/jm950364f

Reference yield:

: 184878-99-7
ethyl (4-isopropylphenoxy)acetate

: 184879-01-4
2-[1-(4-Isopropyl-phenoxy)-2-(2-trifluoromethyl-phenyl)-ethyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / aq. NaOH / tetrahydrofuran / Ambient temperature

2: 82 percent / B(OH)3 / xylene / Heating

3: 1.) BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h

With sodium hydroxide; n-butyllithium; boric acid; In tetrahydrofuran; xylene;
DOI:10.1021/jm950364f