(7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone
• CAS No.: 477848-12-7
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.296
• DSSTox Substance ID: DTXSID801219371
• Nikkaji Number: J3.005.116E
• ChEMBL ID: CHEMBL1381834
• Mol file: 477848-12-7.mol

Synonyms:477848-12-7;(7-methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone;7-methoxy-2-(4-methoxybenzoyl)-1-benzofuran;(7-methoxy-1-benzofuran-2-yl)-(4-methoxyphenyl)methanone;7-Methoxy-2-(4-methoxybenzoyl)benzofuran;Oprea1_137794;MLS000721367;CHEMBL1381834;DTXSID801219371;HMS2682B03;MFCD02081949;AKOS005076121;SMR000335441;10P-935;AO-689/14845002;(7-Methoxy-2-benzofuranyl)(4-methoxyphenyl)methanone

Chemical Property of (7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 282.08920892
• Heavy Atom Count: 21
• Complexity: 362

Purity/Quality:

(7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC3=C(O2)C(=CC=C3)OC

Technology Process of (7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone

There total 4 articles about (7-Methoxy-1-benzofuran-2-yl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 7-methoxy-2-(p-methoxybenzoyl)benzofuran (477848-12-7)

Guidance literature:

With potassium carbonate; In acetonitrile;

DOI:10.1039/b710935k

Reference yield:

C17H16O4 → 7-methoxy-2-(p-methoxybenzoyl)benzofuran (477848-12-7)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 0.916667h; Molecular sieve;

DOI:10.1016/j.tet.2011.08.011

Reference yield:

(Z)-2-(4-methoxybenzylidene)-7-methoxybenzofuran-3(2H)-one (1336877-79-2) → 7-methoxy-2-(p-methoxybenzoyl)benzofuran (477848-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

2: hydrogenchloride; water / acetonitrile / 0.25 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 0.92 h / 20 °C / Molecular sieve

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; water; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.08.011

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

2-Bromo-4'-methoxyacetophenone

(Z)-2-(4-methoxybenzylidene)-7-methoxybenzofuran-3(2H)-one

Downstream raw materials:

C₂₈H₂₇NO₅

C₂₃H₂₅NO₄

C₂₃H₂₃NO₅

(R)-(7-methoxybenzofuran-2-yl)(4-methoxyphenyl)methanol

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